Hearing: A gene for deaf ears?

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Hearing: A gene for deaf ears? Jonathan Ashmore Current Biology Volume 5, Issue 7, Pages 716-718 (July 1995) DOI: 10.1016/S0960-9822(95)00142-4

Figure 1 Cross section of the mammalian cochlear duct (the organ of Corti is enlarged) showing possible targets of genetic mutations leading to hearing losses: hair cells (pink); tectorial membrane (light blue), which contains collagens and tectorins [5]; non-sensory cells of the organ of Corti (yellow); basilar membrane (lilac), which establishes cochlear mechanics; stria vascularis (orange), which maintains endocochlear potential; cochlear morphogenesis — for example, development of the embedding bone (light grey). Current Biology 1995 5, 716-718DOI: (10.1016/S0960-9822(95)00142-4)

Figure 2 Hair cell structure. Actin-filled stereocilia project from the apical end and are displaced by the stimulus. Myosin immunoreactivity is reported in hair cells on and below the stereocilia and below the nucleus. Inset shows tip-links between stereocilia. The tip-links, it is proposed [10], gate the mechano-electrical transducer channels in the membrane and are retensioned by a cluster of myosin molecules which continuously slide up along the actin core of the stereocilia. Current Biology 1995 5, 716-718DOI: (10.1016/S0960-9822(95)00142-4)