Short- and long-term efficacy of prednisolone for first acute rhinovirus-induced wheezing episode Tuomas Jartti, MD, Riitta Nieminen, BM, Tytti Vuorinen,

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Presentation transcript:

Short- and long-term efficacy of prednisolone for first acute rhinovirus-induced wheezing episode Tuomas Jartti, MD, Riitta Nieminen, BM, Tytti Vuorinen, MD, Pasi Lehtinen, MD, Tero Vahlberg, MSc, James Gern, MD, Carlos A. Camargo, MD, DrPH, Olli Ruuskanen, MD Journal of Allergy and Clinical Immunology Volume 135, Issue 3, Pages 691-698.e9 (March 2015) DOI: 10.1016/j.jaci.2014.07.001 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Study flow chart. ED, Emergency department; ICU, intensive care unit; neg., negative; RV, rhinovirus. Journal of Allergy and Clinical Immunology 2015 135, 691-698.e9DOI: (10.1016/j.jaci.2014.07.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Time to a new physician-confirmed wheezing episode in children randomized to receive prednisolone or placebo for their first rhinovirus-induced wheezing episode. The 2-month time point, which was one of the primary outcomes, has been marked. No difference was found at the 2-month or 12-month time points. Journal of Allergy and Clinical Immunology 2015 135, 691-698.e9DOI: (10.1016/j.jaci.2014.07.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Time to a new physician-confirmed wheezing episode in children randomized to receive prednisolone or placebo for their first rhinovirus-induced wheezing episode. Data are represented according to rhinovirus load. P values for interaction between the study drug and rhinovirus load are shown at the 2-month and 12-month follow-ups. Children with a rhinovirus load of greater than 7000 copies/mL had significantly less recurrence at both time points in the prednisolone group compared with the placebo group (see text for details). All children with a high rhinovirus load in the placebo group had a relapse within 100 days. Journal of Allergy and Clinical Immunology 2015 135, 691-698.e9DOI: (10.1016/j.jaci.2014.07.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 The key questions of parental interview and wheezy questionnaire. Journal of Allergy and Clinical Immunology 2015 135, 691-698.e9DOI: (10.1016/j.jaci.2014.07.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 The key questions of parental interview and wheezy questionnaire. Journal of Allergy and Clinical Immunology 2015 135, 691-698.e9DOI: (10.1016/j.jaci.2014.07.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 The key questions of parental interview and wheezy questionnaire. Journal of Allergy and Clinical Immunology 2015 135, 691-698.e9DOI: (10.1016/j.jaci.2014.07.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Clinical score sheet for hospitalized patients. Journal of Allergy and Clinical Immunology 2015 135, 691-698.e9DOI: (10.1016/j.jaci.2014.07.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Symptom and medication diary for 2 weeks after discharge. Journal of Allergy and Clinical Immunology 2015 135, 691-698.e9DOI: (10.1016/j.jaci.2014.07.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Symptom and medication diary from 2 weeks to 2 months after discharge. Journal of Allergy and Clinical Immunology 2015 135, 691-698.e9DOI: (10.1016/j.jaci.2014.07.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 Symptom and medication diary from 2 months to 12 months after discharge. Journal of Allergy and Clinical Immunology 2015 135, 691-698.e9DOI: (10.1016/j.jaci.2014.07.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions