With Respect to Macrophages, Judge the Liver by Its Cover Ehud Zigmond, Chen Varol  Immunity  Volume 47, Issue 2, Pages 219-221 (August 2017) DOI: 10.1016/j.immuni.2017.07.022 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 With Respect to Macrophage Compartment, Judge the Liver by Its Cover Schematic illustration of liver macrophage compartmentalization as a book that contains two distinct resident macrophage populations differing in their location, ontogeny, molecular signature, and function. Accordingly, the renowned KCs reside inside the book in the intravascular space of the liver sinusoids, where they are specialized in clearance of blood-borne pathogens and deleterious substances arriving from the systemic and portal circulation. They are characterized as CLEC4F+F4/80+Tim4+CX3CR1− cells and self-maintain through adulthood independently of BM hematopoiesis. Sierro et al. (2017) uncover a novel liver-resident macrophage subset that forms a contiguous cellular network in the cover of the book that is the hepatic capsule. These cells, named LCMs, are characterized as CX3CR1+F4/80+Tim4−CLEC4F−, and many are uniquely positive for the C-type lectin langerin. By extending dendrites, LCMs specialize in immunosurveillance of pathogens reaching the liver capsule from the peritoneum. In case of peritoneal infection, they are capable of recruiting neutrophils that cooperate in eliminating the capsule-invading bacteria. LCMs originate from BM monocytes in a CSF-1-dependent pathway. Immunity 2017 47, 219-221DOI: (10.1016/j.immuni.2017.07.022) Copyright © 2017 Elsevier Inc. Terms and Conditions