No GH (n=19) Treated with GH (n=67) Mean (SD) Range Mean (SD) Range

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Presentation transcript:

Somatic and cardiac dimensions in GH-treated versus untreated patients with TS No GH (n=19) Treated with GH (n=67) Mean (SD) Range Mean (SD) Range P value Age (years) 16.5 (4.8) 10 to 25 16.1 (4.3) 10 to 25 .727 Height (cm) 138.6 (11.2) 115.0 to 157.1 145.7 (9.4) 122.0 to 162.7 .004 Weight (kg) 47.4 (16.4) 25.8 to 96.4 50.1 (13.8) 24.2 to 84.9 .309 BMI (kg/m²) 24.2 (5.7) 15.6 to 39.1 23.3 (4.9) 15.4 to 39.4 .855 BSA (m²) 1.3 (0.2) 1.0 to 2.0 1.4 (0.2) 0.9 to 1.9 .070 Septum/BSA (mm/m²) 5.4 (0.9) 4.1 to 6.3 5.2 (0.8) 3.7 to 7.4 .367 PW/BSA (mm/m²) 5.4 (0.9) 4.1 to 6.3 5.1 (0.7) 3.5 to 6.6 .057 LVIDD diastole/BSA (mm/m²) 30.5 (4.4) 22.0 to 39.8 30.5 (4.4) 22.4 to 41.3 .970 LVIDD systole/BSA (mm/m²) 19.2 (2.2) 15.4 to 22.5 19.1 (3.4) 12.0 to 27.9 .948 LVM/BSA (g/m²) 59.1 (16.2) 39.3 to 108.8 63.4 (12.5) 40.6 to 90.7 .224 Fractional shortening 36.1 (8.1) 27.0 to 50.0 37.6 (6.1) 25.0 to 53.7 .422 E/A ratio 1.8 (0.6) 1.0 to 3.2 1.7 (0.5) 1.1 to 3.4 .319 DT 125.1 (36.3) 80.7 to 208.0 140.8 (68.0) 63.6 to 451.0 .409 DT, Mitral deceleration time. E/A ratio is the peak flow velocity in early diastole (E wave) versus that a atrial contraction (A wave). Mean values are compared by analysis of variance, with age as a covariate, followed by Fisher‘s probable least squares difference test. Cardiac measurements are normalized to BSA. Fractional shortening = (LVIDD-IVS)/LVIDD Abbildung mod. nach Matura, 2007

Effect of GH treatment on septum, PW, LVIDD disastole, LVIDD systole, and LVM, controlling for age, years receiving GH therapy, and BSA Cardiac dimension Estimate SE t ratio P value Septum R² = 0.246, P = .0004, n = 67 Intercept 3.604 0.814 4.430 < .0001 Age 0.013 0.039 0.335 .739 Years on GH 0.002 0.043 0.042 .966 BSA 2.363 0.800 2.952 .004 Septum R² = 0.246, P = .0004, n = 67 Intercept 2.643 0.679 3.892 .0002 Age - 0.003 0.033 0.092 .927 Years on GH - 0.005 0.036 0.138 .891 BSA 3.172 0.668 4.748 < .0001 LVID diastole R² = 0.222, P = .001, n = 67 Intercept 29.230 3.147 9.288 < .0001 Age 0.045 0.151 0.300 .765 Years on GH 0.032 0.166 0.193 .848 BSA 8.422 3.096 2.720 .008 Abbildung mod. nach Matura, 2007

Effect of GH treatment on septum, PW, LVIDD disastole, LVIDD systole, and LVM, controlling for age, years receiving GH therapy, and BSA Cardiac dimension Estimate SE t ratio P value LVID systole R² = 0.116, P = .050, n = 67 Intercept 20.344 2.817 7.223 < .0001 Age 0.022 0.135 0.162 .872 Years on GH 0.232 0.149 1.559 .124 BSA 3.140 2.771 1.133 .261 PW R² = 0.017, P = .778, n = 67 Intercept 80.418 20.737 3.878 .0003 Age -0.954 0.996 - 0.958 .342 Years on GH -0.401 1.094 - 0.367 .715 BSA 14.317 20.399 0.702 < .485 Abbildung mod. nach Matura, 2007