Peter König, MD, PhD Journal of Allergy and Clinical Immunology

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Presentation transcript:

The effects of cromolyn sodium and nedocromil sodium in early asthma prevention Peter König, MD, PhD Journal of Allergy and Clinical Immunology Volume 105, Issue 2, Pages S575-S581 (February 2000) DOI: 10.1016/S0091-6749(00)90061-7 Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 1 Asthma severity classifications at end of the study. Severity categories are shown according to the original 3 treatment groups (as needed: β-agonist, mild asthma; cromolyn sodium, moderate asthma; inhaled corticosteroids, severe asthma). Open bars represent patients who were free of symptoms (not receiving any antiasthma medications); light gray bars represent patients with mild asthma (treated with bronchodilators only, as needed); dark gray bars represent patients with moderate asthma (treated with cromolyn sodium); black bars represent patients with severe asthma (treated with inhaled corticosteroids). (From König P, Shaffer J. The effect of drug therapy on long-term outcome of childhood asthma: a possible preview of the international guidelines. J Allergy Clin Immunol 1996;98:1103-11. By permission.) Journal of Allergy and Clinical Immunology 2000 105, S575-S581DOI: (10.1016/S0091-6749(00)90061-7) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 2 Pulmonary function tests at start and end of follow-up. FVC, Forced vital capacity; FEF 25-75, forced expiratory flow; A , mild asthma (bronchodilators, as needed); B , moderately severe asthma (cromolyn sodium); C , severe asthma (inhaled corticosteroids). (Modified from König P, Shaffer J. The effect of drug therapy on long-term outcome of childhood asthma: a possible preview of the international guidelines. J Allergy Clin Immunol 1996;98:1103-11. By permission.) Journal of Allergy and Clinical Immunology 2000 105, S575-S581DOI: (10.1016/S0091-6749(00)90061-7) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 3 Change in pulmonary function from start to end of initial treatment with either β-agonists, sodium cromolyn, or inhaled corticosteroids. All values are prebronchodilator use. FVC , Forced vital capacity; FEF 25-75, forced expiratory flow; PRN , as needed. (From König P. Evidence for benefits of early intervention with non-steroidal drugs in asthma. Pediatr Pulmonol 1997; 15(suppl):34-9. Copyright 1997. Reprinted by permission of Wiley–Liss, Inc., a subsidiary of John Wiley & Sons, Inc.) Journal of Allergy and Clinical Immunology 2000 105, S575-S581DOI: (10.1016/S0091-6749(00)90061-7) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 4 Children with at least 1 physician-diagnosed wheezing episode during anti-inflammatory therapy administered after bronchiolitis. For weeks 1 to 8, P = .35; weeks 9 to 16, P = .01; weeks 1 to 16, P = .08. Asterisks indicate that, in weeks 9 to 16, P < .05 compared with patients in the control group (χ2 test). (From Reijonen T, Korppi M, Kuikka L, Remes K. Anti-inflammatory therapy reduces wheezing after bronchiolitis. Arch Pediatr Adolesc Med 1996;150:512-7. Copyright 1996, American Medical Association.) Journal of Allergy and Clinical Immunology 2000 105, S575-S581DOI: (10.1016/S0091-6749(00)90061-7) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 5 Growth suppression with inhaled corticosteroids in severe versus mild asthma. (From König P. Evidence for benefits of early intervention with non-steroidal drugs in asthma. Pediatr Pulmonol 1997;15(suppl):34-9. Copyright 1999. Reprinted by permission of Wiley–Liss, Inc., a subsidiary of John Wiley & Sons, Inc.) Journal of Allergy and Clinical Immunology 2000 105, S575-S581DOI: (10.1016/S0091-6749(00)90061-7) Copyright © 2000 Mosby, Inc. Terms and Conditions