Volume 95, Issue 3, Pages (March 2019)

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Volume 95, Issue 3, Pages 518-525 (March 2019) Would hemodialysis patients benefit from a Staphylococcus aureus vaccine? Roisin Connolly, Mark D. Denton, Hilary Humphreys, Rachel M. McLoughlin Kidney International Volume 95, Issue 3, Pages 518-525 (March 2019) DOI: 10.1016/j.kint.2018.10.023 Copyright © 2019 International Society of Nephrology Terms and Conditions

Figure 1 Potential correlates of immunity for an effective Staphylococcus aureus vaccine. The ideal S aureus vaccine would comprise appropriate antigens and adjuvant capable of driving both antibody and T-cell responses. Antibodies are required to neutralize secreted toxins and facilitate phagocytosis by opsonization of the bacteria. The induction of memory T-helper cell 1 (Th1) and/or T-helper cell 17 (Th17) cell responses would in turn recruit and activate phagocytes, leading to the destruction and removal of the organism. Induction of follicular T-helper cells (Tfh) is also desirable to promote antibody responses. APC, antigen-presenting cell; CXCL, chemokine ligand; IFN-γ, interferon-γ; IL, interleukin; PRR, pattern recognition receptor; SA-BSI, Staphylococcus aureus bloodstream infection. Kidney International 2019 95, 518-525DOI: (10.1016/j.kint.2018.10.023) Copyright © 2019 International Society of Nephrology Terms and Conditions