Paul M. O’Byrne, MB, FRCPI, FRCP(C)a, Soren Pedersen, MD, PhDb

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Presentation transcript:

Measuring efficacy and safety of different inhaled corticosteroid preparations Paul M. O’Byrne, MB, FRCPI, FRCP(C)a, Soren Pedersen, MD, PhDb Journal of Allergy and Clinical Immunology Volume 102, Issue 6, Pages 879-886 (December 1998) DOI: 10.1016/S0091-6749(98)70322-7 Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 Chemical structures of the inhaled corticosteroids currently available to treat asthma. Journal of Allergy and Clinical Immunology 1998 102, 879-886DOI: (10.1016/S0091-6749(98)70322-7) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 2 Mean changes from baseline in morning peak expiratory flow (PEF) in patients treated with placebo or various doses of budesonide for 12 weeks of treatment. Significant dose-response is demonstrated; however, the difference between placebo and budesonide 100 μg twice daily is greater than that between 100 and 800 μg twice daily.29 Journal of Allergy and Clinical Immunology 1998 102, 879-886DOI: (10.1016/S0091-6749(98)70322-7) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 3 Schematic dose-response curves for the wanted and unwanted effects of inhaled corticosteroids. The range in which the risk:benefit ratio is favorable is that at which the wanted effects in the lungs increase steeply with dose while the unwanted systemic effects increase gradually. At higher doses, the increase in risk greatly outweighs the slight remaining increase in benefit. This relationship appears to vary for different inhaled corticosteroids. Reprinted with permission from Allergy. 1997;52:1-34. Journal of Allergy and Clinical Immunology 1998 102, 879-886DOI: (10.1016/S0091-6749(98)70322-7) Copyright © 1998 Mosby, Inc. Terms and Conditions