Dominique A. Joly, Jean-Pierre Grünfeld Kidney International

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Presentation transcript:

3-Nitrotyrosine as a biomarker for vascular involvement in Fabry disease Dominique A. Joly, Jean-Pierre Grünfeld Kidney International Volume 86, Issue 1, Pages 5-7 (July 2014) DOI: 10.1038/ki.2014.126 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Putative mechanism linking α-galactosidase A (α-GalA) deficiency and endothelial nitric oxide synthase uncoupling. Following α-GalA deficiency globotriaosylceramide (Gb3) accumulates within caveolae of endothelial cells. As a consequence, endothelial nitric oxide synthase (eNOS) is uncoupled, resulting in superoxide (O2–) production; NO is consumed to form peroxynitrite (ONOO–), which leads to the formation of 3-nitrotyrosine (3NT). Kidney International 2014 86, 5-7DOI: (10.1038/ki.2014.126) Copyright © 2014 International Society of Nephrology Terms and Conditions