Calcium citrate ameliorates the progression of chronic renal injury

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Presentation transcript:

Calcium citrate ameliorates the progression of chronic renal injury Liliana Gadola, Oscar Noboa, María Natalia Márquez, María José Rodriguez, Nicolás Nin, José Boggia, Alejandro Ferreiro, Silvia García, Virginia Ortega, María Luisa Musto, Paolo Ponte, Pablo Sesser, Carlos Pizarrosa, Silvana Ravaglio, Ana Vallega Kidney International Volume 65, Issue 4, Pages 1224-1230 (April 2004) DOI: 10.1111/j.1523-1755.2004.00496.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Histologic sections of kidney from 5/6 nephrectomized Wistar rat. Immunohistochemistry staining. Representative results are shown. (A) Glomerular and tubulointerstitial proliferating cell nuclear antigen (PCNA) immunostaining in rats 1week after 5/6 nephrectomy (NFX). Sections were counterstained with eosin (original magnification ×200), and (B) from a calcium citrate–treated animal (NFX-CIT). Sections were counterstained with eosin (original magnification ×200). (C) Immunohistochemical detection of α-smooth muscle actin in rats 10weeks after 5/6 nephrectomy (original magnification ×400), and (D) from a calcium citrate–treated animal (NFX-CIT) that shows positive staining only in arterioles (original magnification ×400). (E) Immunohistochemical detection of desmin in rats 10weeks after 5/6 nephrectomy (original magnification ×400), and (F) from a calcium citrate–treated animal (NFX-CIT) that shows positive staining only in arterioles (original magnification ×400). (G) Periodic-acid Schiff (PAS) staining in rats 20weeks after nephrectomy showing glomerulosclerosis, tubular atrophy, and interstitial infiltration (original magnification ×200), and (H) from a calcium citrate–treated animal (NFX-CIT) (original magnification ×200). Kidney International 2004 65, 1224-1230DOI: (10.1111/j.1523-1755.2004.00496.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 Correlation between proteinuria and tubulointerstitial score at 20weeks. (R2= 0.6, P < 0.05). Kidney International 2004 65, 1224-1230DOI: (10.1111/j.1523-1755.2004.00496.x) Copyright © 2004 International Society of Nephrology Terms and Conditions