Vitamin D: The Iceberg Nutrient

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Presentation transcript:

Vitamin D: The Iceberg Nutrient Laura A.G. Armas, MD, Robert P. Heaney, MD Journal of Renal Nutrition Volume 21, Issue 2, Pages 134-139 (March 2011) DOI: 10.1053/j.jrn.2010.09.002 Copyright © 2011 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Native vitamin D is obtained through food or the skin. It is hydroxylated in the liver to form 25-hydroxyvitamin D (25(OH)D). It is then hydroxylated by a 1-α-hydroxylase enzyme in the kidney to form 1,25(OH)2D. Alternatively, 25(OH)D can be hydroxylated to form 1,25(OH)2D by other cells. This 1,25(OH)2D is used in an autocrine manner for internal regulation of the host cells DNA. For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article. (Copyright Robert P. Heaney, 2010. Used with permission). Journal of Renal Nutrition 2011 21, 134-139DOI: (10.1053/j.jrn.2010.09.002) Copyright © 2011 National Kidney Foundation, Inc. Terms and Conditions