Lisofylline suppresses ex vivo release by murine spleen cells of hematopoietic inhibitors induced by cancer chemotherapeutic agents Peter de Vries, Jack.

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Lisofylline suppresses ex vivo release by murine spleen cells of hematopoietic inhibitors induced by cancer chemotherapeutic agents Peter de Vries, Jack W Singer Experimental Hematology Volume 28, Issue 8, Pages 916-923 (August 2000) DOI: 10.1016/S0301-472X(00)00493-8

Figure 1 Pretreatment with LSF abrogates BFU-E growth inhibitory activity induced by cancer chemotherapeutic agents. Effect of spleen cell CM from mice treated with VP-16 (75 mg/kg), CisP (8 mg/kg), or Melph (40 mg/kg), either with control vehicle or in combination with LSF (100 mg/kg) on BFU-E growth, is shown. Control vehicle and LSF were administered at the noted time intervals before administration of the chemotherapeutic agents. Each bar represents the mean colony counts obtained from 10 individually tested spleen cell CM (each tested in triplicate) ± 1 SD. p < 0.05 vs *control CM or OChemotherapeutic agent alone CM Experimental Hematology 2000 28, 916-923DOI: (10.1016/S0301-472X(00)00493-8)

Figure 2 Treatment with AraC leads to release of cytokines at concentrations and combinations that inhibit HPP-CFC colony formation. Pooled CM from five mice treated with control vehicle (top right) or AraC (bottom right) were treated with RPMI-1640 supplemented medium (control, no antibodies) (top left) or neutralizing antibodies (Abs) against known growth inhibitors (panels on the right). Each bar represents the mean HPP-CFC number ± 1 SD. The horizontal bar represents the mean number of colonies in the control without Abs ± 1 SD Experimental Hematology 2000 28, 916-923DOI: (10.1016/S0301-472X(00)00493-8)

Figure 3 Treatment with AraC or Melph leads to release of cytokines at concentrations and combinations that inhibit CFU-MIX colony formation. Pooled CM from five mice treated with control vehicle (top right), AraC (middle right), or Melph (bottom right) were treated with RPMI-1640 supplemented medium (control no antibodies) (top left) or neutralizing antibodies (Abs) against known inhibitory molecules (panels on the right). Each bar represents the mean CFU-MIX number ± 1 SD. The horizontal bar represents the mean number of colonies in the control without Abs ± 1 SD Experimental Hematology 2000 28, 916-923DOI: (10.1016/S0301-472X(00)00493-8)

Figure 4 Pretreatment with LSF abrogates the induction of negative regulators for BFU-E colony formation by Melph. Pooled CM from five mice treated with control vehicle (top right), Melph (middle right), or LSF + Melph (bottom right) were treated with RPMI-1640 supplemented medium (control, no antibodies) (top left) or neutralizing antibodies (Abs) against known growth inhibitors (panels on the right). Each bar represents the mean BFU-E number ± 1 SD. The horizontal bar represents the mean number of colonies in the control without Abs ± 1 SD Experimental Hematology 2000 28, 916-923DOI: (10.1016/S0301-472X(00)00493-8)