Adenosine instead of supranormal potassium in cardioplegia: It is safe, efficient, and reduces the incidence of postoperative atrial fibrillation. A randomized.

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Presentation transcript:

Adenosine instead of supranormal potassium in cardioplegia: It is safe, efficient, and reduces the incidence of postoperative atrial fibrillation. A randomized clinical trial Øyvind Jakobsen, MD, PhD, Torvind Næsheim, MD, Kathrine Nergård Aas, MD, Dag Sørlie, MD, PhD, Tor Steensrud, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 145, Issue 3, Pages 812-818 (March 2013) DOI: 10.1016/j.jtcvs.2012.07.058 Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Release of troponin T and creatine kinase MB (CKMB) preoperatively (pre) and 0 to 48 hours postoperatively in patients receiving hyperkalemic cardioplegia (closed circles, n = 28) or cardioplegia with 1.2 mmol/L of adenosine instead of supranormal potassium (open circles, n = 24). Data are given as mean and error bars denote standard deviation. Patients reoperated on owing to bleeding and patients receiving both adenosine and hyperkalemic cardioplegia are excluded. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 812-818DOI: (10.1016/j.jtcvs.2012.07.058) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Cardiac index and systemic vascular resistance index measured immediately before surgery (preop), after sternal closure (postop), immediately after arrival at the intensive care unit (arrival ICU), and 4, 8, and 12 hours after arrival at the ICU. Heart rate and mean arterial pressure were measured immediately after arrival at the ICU and 4, 8 and 12 hours after arrival at the ICU. All parameters were measured with PiCCO arterial thermodilution catheters in patients receiving either hyperkalemic cardioplegia (closed circles, n = 28) or adenosine cardioplegia (open circles, n = 24). Data are given as mean and error bars denote standard deviation. Patients reoperated on owing to bleeding and patients receiving both adenosine and hyperkalemic cardioplegia were excluded. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 812-818DOI: (10.1016/j.jtcvs.2012.07.058) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions