Osteoarthritis and Cartilage

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Osteoarthritis and Cartilage Osteoarthritis development in a surgically induced rat model is attenuated by treatment with micronized amniotic membrane N.J. Willett, T. Thote, A.S. Lin, S. Moran, Y. Raji, H.Y. Stevens, R.E. Guldberg Osteoarthritis and Cartilage Volume 21, (April 2013) DOI: 10.1016/j.joca.2013.02.081 Copyright © 2013 Terms and Conditions

Figure 1 Histology from MMT animals with saline or amnion treatment. H&E images (10×) showed the presence of amnion particles (black arrows) in the synovium 3 days post-injection. Saf-O staining 21 days post-injection showed healthy cartilage and more proteoglycans staining in MMT animals treated with amnion. Osteoarthritis and Cartilage 2013 21, DOI: (10.1016/j.joca.2013.02.081) Copyright © 2013 Terms and Conditions

Figure 2 EPIC-μCT data 21 days after MMT surgery. Reconstructions of the tibial articular cartilage with attenuation heat maps show lesions in the saline treated animals and sites of erosion in the amnion treated animals. No lesions were observed in the amnion treated animals. Saline treated MMT animals showed a loss of proteoglycans (higher attenuation) while amnion treated animals showed proteoglycan levels comparable to the non-MMT control. Osteoarthritis and Cartilage 2013 21, DOI: (10.1016/j.joca.2013.02.081) Copyright © 2013 Terms and Conditions