FIGURE 1 PRISMA flow diagram of studies in systematic review

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FIGURE 1 PRISMA flow diagram of studies in systematic review FIGURE 1 PRISMA flow diagram of studies in systematic review. PRISMA, Preferred Reporting Items for Systematic Reviews ... FIGURE 1 PRISMA flow diagram of studies in systematic review. PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Unless provided in the caption above, the following copyright applies to the content of this slide: Copyright © American Society for Nutrition 2019.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Am J Clin Nutr, Volume 109, Issue 4, 04 April 2019, Pages 1098–1111, https://doi.org/10.1093/ajcn/nqy376 The content of this slide may be subject to copyright: please see the slide notes for details.

FIGURE 2 Forest plot of integrative symptom score, severity of abdominal pain, bloating, and flatulence in randomized ... FIGURE 2 Forest plot of integrative symptom score, severity of abdominal pain, bloating, and flatulence in randomized controlled trials comparing prebiotic to placebo in adults with IBS or other FBDs. Values were calculated as standardized mean differences (95% CI) for clinical outcomes using a random effects model. FBD, functional bowel disorder; IBS, irritable bowel syndrome; Std., standard. Unless provided in the caption above, the following copyright applies to the content of this slide: Copyright © American Society for Nutrition 2019.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Am J Clin Nutr, Volume 109, Issue 4, 04 April 2019, Pages 1098–1111, https://doi.org/10.1093/ajcn/nqy376 The content of this slide may be subject to copyright: please see the slide notes for details.

FIGURE 3 Forest plot of subgroup analysis of prebiotic type (ITF vs FIGURE 3 Forest plot of subgroup analysis of prebiotic type (ITF vs. non-inulin-type fructan) on integrative symptom ... FIGURE 3 Forest plot of subgroup analysis of prebiotic type (ITF vs. non-inulin-type fructan) on integrative symptom score, severity of abdominal pain, bloating, and flatulence in randomized controlled trials comparing prebiotic to placebo in adults with IBS or other FBDs. One outlier study was removed, and values were calculated as standardized mean differences (95% CI) for clinical outcomes using a random effects model. FBD, functional bowel disorder; IBS, irritable bowel syndrome; ITF, inulin-type fructan; Std., standard. Unless provided in the caption above, the following copyright applies to the content of this slide: Copyright © American Society for Nutrition 2019.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Am J Clin Nutr, Volume 109, Issue 4, 04 April 2019, Pages 1098–1111, https://doi.org/10.1093/ajcn/nqy376 The content of this slide may be subject to copyright: please see the slide notes for details.

FIGURE 4 Forest plot of subgroup analysis of different prebiotic dose (≤6 g/d vs. >6 g/d) on integrative symptom ... FIGURE 4 Forest plot of subgroup analysis of different prebiotic dose (≤6 g/d vs. >6 g/d) on integrative symptom score, severity of abdominal pain, bloating, and flatulence in randomized controlled trials comparing prebiotic to placebo in adults with IBS or other FBDs. One outlier study was removed, and values were calculated as standardized mean differences (95% CI) for clinical outcomes using a random effects model. FBD, functional bowel disorder; IBS, irritable bowel syndrome; Std., standard. Unless provided in the caption above, the following copyright applies to the content of this slide: Copyright © American Society for Nutrition 2019.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Am J Clin Nutr, Volume 109, Issue 4, 04 April 2019, Pages 1098–1111, https://doi.org/10.1093/ajcn/nqy376 The content of this slide may be subject to copyright: please see the slide notes for details.

FIGURE 5 Forest plot of absolute abundance of fecal bifidobacteria and lactobacilli in randomized controlled trials ... FIGURE 5 Forest plot of absolute abundance of fecal bifidobacteria and lactobacilli in randomized controlled trials comparing prebiotic to placebo in adults with IBS or other FBDs. Values were calculated as weighted mean differences (95% CI) using a random effects model. FBD, functional bowel disorder; IBS, irritable bowel syndrome. Unless provided in the caption above, the following copyright applies to the content of this slide: Copyright © American Society for Nutrition 2019.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Am J Clin Nutr, Volume 109, Issue 4, 04 April 2019, Pages 1098–1111, https://doi.org/10.1093/ajcn/nqy376 The content of this slide may be subject to copyright: please see the slide notes for details.

FIGURE 6 Risk of bias in (A) individual studies and (B) overall for each category of randomized controlled trial ... FIGURE 6 Risk of bias in (A) individual studies and (B) overall for each category of randomized controlled trial comparing prebiotic to placebo in adults with IBS or other FBDs. FBD, functional bowel disorder; IBS, irritable bowel syndrome. Unless provided in the caption above, the following copyright applies to the content of this slide: Copyright © American Society for Nutrition 2019.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Am J Clin Nutr, Volume 109, Issue 4, 04 April 2019, Pages 1098–1111, https://doi.org/10.1093/ajcn/nqy376 The content of this slide may be subject to copyright: please see the slide notes for details.