Timeline of major events in influenza vaccine development.

Slides:



Advertisements
Similar presentations
Swine Flu Presenter: Ali Azarashk. Overview Introduction Classification History Transmission Signs and Symptoms Treatment.
Advertisements

What Is H1N1 (Swine Flu) Pandemic Influenza? Colorized image of H1N1 from a transmission electron micrograph. Source: CDC.
C.-S. Lee, J.-H. Lee  Clinical Microbiology and Infection 
C.-S. Lee, J.-H. Lee  Clinical Microbiology and Infection 
Current position of MALDI-TOF MS in the workflow of the clinical microbiology laboratory, including the current options for analysis of bacteria directly.
Overview of potential risk or protective factors influencing the horizontal or vertical transmission of Neospora caninum and the occurrence of exogenous.
Proposed informatics pipeline for microbial genomic analysis in the clinical microbiology laboratory. Proposed informatics pipeline for microbial genomic.
Itraconazole tissue and fluid concentrations in humans as multiples of the maximal or simultaneously measured concentration in plasma (μg/ml) after systemic.
Voriconazole tissue and fluid concentrations in humans as multiples of the maximal or simultaneously measured concentration in plasma (μg/ml) after systemic.
Functional range and environmental niches of the Pseudomonas genus, highlighting the broad distribution of the P. fluorescens species complex. Functional.
Time line of the discovery of the species belonging to the genus Staphylococcus. Time line of the discovery of the species belonging to the genus Staphylococcus.
MIC distributions of selected β-lactam antimicrobial agents for H
Characterization of oprD promoter elements.
Phylogenetic tree constructed by the neighbor-joining method, showing the position of Peptostreptococcus species within Clostridium rRNA clusters XI, XIII,
Phylogenetic tree of 38 Pseudomonas type strains, based on the V3-V5 region sequence of the 16S rRNA gene (V3 primer, positions 442 to 492; and V5 primer,
History of antiviral drugs approved between January 1959 and April History of antiviral drugs approved between January 1959 and April (A) Approved.
RND efflux operons in P. aeruginosa.
Neighbor-joining dendrogram based on concatenated gene fragments of adk, atpG, frdB, mdh, pgi, and recA (2,712 nucleotides), comparing the type strains.
Phylogenetic comparison of the capsule biosynthesis (cap) gene locus among selected Pasteurella multocida strains. Phylogenetic comparison of the capsule.
Approximate numbers of cases per 100,000 individuals caused by penicillin resistance for each year (left). Approximate numbers of cases per 100,000 individuals.
Adenoviremia with multiple HAdV species.
Modelling during an emergency: the 2009 H1N1 influenza pandemic
Relative abundances of Propionibacterium species in different skin areas determined by 16S rRNA gene sequence analysis of 10 individuals. Relative abundances.
Drinking water-associated disease outbreaks (n = 780) reported to WBDOSS by state, , including 15 single cases. Drinking water-associated disease.
Temporal correlation between intestinal HAdV infection and viremia.
Glucose concentration-dependent increase of melanin synthesis.
Diagnostic testing in Ebola virus outbreaks.
Phylogenetic comparison among selected Pasteurella multocida and Haemophilus influenzae species with completed genome sequences. Phylogenetic comparison.
Molecular surface models of the active-site cleft of the OXA-51-like enzymes. Molecular surface models of the active-site cleft of the OXA-51-like enzymes.
Increasing prevalence of multidrug resistance among P
Transmission electron micrograph of M
Fluconazole tissue and fluid concentrations in humans as multiples of the maximal or simultaneously measured concentration in plasma (μg/ml) after systemic.
Number of outbreaks associated with drinking water by water system type and year (n = 780), 1971 to “Other” includes outbreaks associated with bottled.
The three 16S rRNA gene helix 18 types present in a collection of isolates from the H. influenzae group, represented by H. influenzae strain Rd, cryptic.
Percentages of outbreak deficiencies (n = 671) in public water systems (n = 656) by time period, 1971 to 2006, excluding outbreaks associated with Legionella.
Malaria mortality in the 20th century.
Schematic representing the activation of the complement cascade.
Drug transport mechanism of AcrB.
(Top) Graph illustrating citations in books for Plasmodium falciparum and Plasmodium vivax from 1900 to 2008, generated by use of the tool at
Number of outbreaks associated with drinking water by system type and month (n = 762), 1971 to 2006, excluding outbreaks associated with commercially bottled.
Fabrizio Dutly, and Martin Altwegg Clin. Microbiol. Rev. 2001; doi:10
Hector H. García et al. Clin. Microbiol. Rev. 2002; doi: /CMR
Schematic representation of the progress in the development of vaccines against the most recent pandemic and seasonal H1N1 influenza virus strains. Schematic.
Publications on biosensors for the field in general compared with the specific detection of whole bacteria. Publications on biosensors for the field in.
Malaria mortality in the 20th century.
Minimum-spanning-tree analysis of 59 C
Roberta B. Carey et al. Clin. Microbiol. Rev. 2018; doi: /CMR
Various possible courses of the immune response to severe sepsis and septic shock over 28 days. Various possible courses of the immune response to severe.
Forest plot of clinical trials reporting efficacy of acellular and whole-cell pertussis vaccines (38, 404, 590 – 593). Forest plot of clinical trials reporting.
Identification algorithm combining the use of commercial DNA probes (rounded rectangles and squares) and genetic sequencing (ellipses). Identification.
Sequence of helix 18 of the 16S rRNA genes (corresponding to Escherichia coli positions 430 to 500) of different Mycobacterium species. Sequence of helix.
Stages of biofilm development (214).
(A) Crystal structure of the hemagglutinin (HA) trimer.
Effect of detergent and disinfectant cleaning on total Staphylococcus aureus (methicillin-susceptible S. aureus [MSSA] and methicillin-resistant S. aureus.
Simplified representation of the reverse genetic approach used to construct the chimera vaccine Poulvac FluFend i AI H5N3 RG to protect poultry against.
Percentages of outbreak deficiencies in public water systems associated with untreated and improperly treated source water by year, 1971 to 2006, excluding.
Human-bovine rotavirus reassortant vaccine (RotaTeq).
Pathogenesis of oncogenic HPV
Maximum likelihood nucleotide tree of the bla OXA-51-like genes intrinsic to A. baumannii. Maximum likelihood nucleotide tree of the blaOXA-51-like genes.
Adherence patterns of enteropathogenic E
(A to E) Scanning electron micrographs of S
Relationship between MIC, dose of fluconazole, and emergence/expression of specific resistance mechanisms in oropharyngeal candidiasis. •, MIC of fluconazole.
Phylogenetic tree of the complete genomes of 27 representative human (black) and camel (red) MERS-CoV strains rooted by NeoCoV (KC ). Phylogenetic.
Characterization of CWR22 xenografts and XMRV-related sequences.
Molecular surface models of the active-site cleft of OXA-66 (A) and OXA-40 (B), showing the absence of a hydrophobic bridge in OXA-66. Molecular surface.
Comparison of the van gene clusters.
Distribution of foci of endemicity and outbreaks of visceral leishmaniasis (VL). Distribution of foci of endemicity and outbreaks of visceral leishmaniasis.
Effects of acute malnutrition on lymphoid and hematopoietic organs.
Live/Dead-stained fluorescence microscopy images of in vitro PEG tube surface biofilms grown in chemostats at pH 6.0 (A), pH 5.0 (B), pH 4.0 (C), and pH.
Human cytomegalovirus vaccine development strategies.
Presentation transcript:

Timeline of major events in influenza vaccine development. Timeline of major events in influenza vaccine development. Influenza pandemics and major H5N1 outbreaks are indicated in red, while major breakthroughs in influenza vaccine development are highlighted in blue. Superscript numbers indicate references. *, see the FDA website (http://www.fda.gov/); ∧, see the European Medicines Agency website (http://www.ema.europa.eu); #, see the CDC website (http://www.cdc.gov/vaccines/acip/index.html). Sook-San Wong, and Richard J. Webby Clin. Microbiol. Rev. 2013; doi:10.1128/CMR.00097-12