Histological changes in mouse colons after DSS treatment.

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Histological changes in mouse colons after DSS treatment. Histological changes in mouse colons after DSS treatment. Representative photomicrographs of colons of DSS-treated WT, IL-1α KO, and cohoused mice, sacrificed on day 8 or 14 (H&E staining, ×200 magnification). (Left) Day 8; (right) day 14. (A and E) WT mice; (B and F) IL-1α KO mice; (C and G) IL-1α cohoused mice; (D and H) cohoused WT mice; (I) means ± SEM of histological scores of colons on days 8 or 14 after the initiation of DSS treatment (8 mice/group). The data are from five independent experiments. *, P < 0.05; **, P < 0.001 (t test). Moran Nunberg et al. mSystems 2018; doi:10.1128/mSystems.00213-17