Degeneration, inflammation, regeneration, and pain/disability in dogs following destabilization or articular cartilage grooving of the stifle joint L.N.

Slides:

Advertisements

Similar presentations

B. J. Kim, D. -W. Kim, S. H. Kim, J. H. Cho, H. J. Lee, D. Y. Park, S

Advertisements

Subchondral plate porosity colocalizes with the point of mechanical load during ambulation in a rat knee model of post-traumatic osteoarthritis H. Iijima,

Alleviation of osteoarthritis by calycosin-7-O-β-d-glucopyranoside (CG) isolated from Astragali radix (AR) in rabbit osteoarthritis (OA) model S.I. Choi,

Non-destructive evaluation of articular cartilage defects using near-infrared (NIR) spectroscopy in osteoarthritic rat models and its direct relation.

Tribological and material properties for cartilage of and throughout the bovine stifle: support for the altered joint kinematics hypothesis of osteoarthritis

Histopathological subgroups in knee osteoarthritis

The groove model of osteoarthritis applied to the ovine fetlock joint

Cartilage degeneration in the goat knee caused by treating localized cartilage defects with metal implants R.J.H. Custers, W.J.A. Dhert, D.B.F. Saris,

The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment T.N.

Establishment of a rabbit model to study the influence of advanced glycation end products accumulation on osteoarthritis and the protective effect of.

L.N. Nwosu, P.I. Mapp, V. Chapman, D.A. Walsh

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in sheep and goats C.B. Little, M.M. Smith, M.A.

Protective effect of a new biomaterial against the development of experimental osteoarthritis lesions in rabbit: a pilot study evaluating the intra-articular.

K. Murata, N. Kanemura, T. Kokubun, T. Fujino, Y. Morishita, K

Calcification of human articular knee cartilage is primarily an effect of aging rather than osteoarthritis H. Mitsuyama, M.D., Ph.D., R.M. Healey, B.S.,

Subchondral plate porosity colocalizes with the point of mechanical load during ambulation in a rat knee model of post-traumatic osteoarthritis H. Iijima,

Whole-body vibration of mice induces articular cartilage degeneration with minimal changes in subchondral bone M.R. McCann, C. Yeung, M.A. Pest, A. Ratneswaran,

Arthroscopic estimation of the extent of chondropathy

Angiogenesis in two animal models of osteoarthritis

Cross-sectional and predictive associations between plasma adipokines and radiographic signs of early-stage knee osteoarthritis: data from CHECK W.E.

Knee osteoarthritis in community-dwelling older adults: are there characteristic patterns of pain location? L.R.J. Wood, Ph.D., M.C.S.P., G. Peat, Ph.D.,

Oral hydrolyzed type 1 collagen induces chondroregeneration and inhibits synovial inflammation in murine posttraumatic osteoarthritis Q.-A. Dar, R.D.

Increase in degraded collagen type II in synovial fluid early in the rabbit meniscectomy model of osteoarthritis E. Lindhorst, M.D., L. Wachsmuth, Ph.D.,

M. E. R. van Meegeren, G. Roosendaal, N. W. D. Jansen, M. J. G

Metabolic Dysregulation Accelerates Progression in Early Degenerative Rat Knee Joints Driven by Local Inflammatory Changes H.M. de Visser, S.C. Mastbergen,

Biomechanical, histologic and macroscopic assessment of articular cartilage in a sheep model of osteoarthritis S.P. Oakley, M.N. Lassere, I. Portek,

Characterization of mature vs aged rabbit articular cartilage: analysis of cell density, apoptosis-related gene expression and mechanisms controlling.

G. Venne, S. Pang, Y. Tse, R. Ellis Osteoarthritis and Cartilage

Sustained clinical and structural benefit after joint distraction in the treatment of severe knee osteoarthritis K. Wiegant, P.M. van Roermund, F. Intema,

The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone K. Takebe, M.F. Rai, E.J. Schmidt,

Biochemical markers of joint tissue damage increase shortly after a joint bleed; an explorative human and canine in vivo study L.F.D. van Vulpen, M.E.R.

Protective effects of a cathepsin K inhibitor, SB , in the canine partial medial meniscectomy model of osteoarthritis J.R. Connor, C. LePage, B.A.

Very rapid clearance after a joint bleed in the canine knee cannot prevent adverse effects on cartilage and synovial tissue N.W.D. Jansen, Ph.D., G.

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the rat N. Gerwin, A.M. Bendele, S. Glasson,

A. Ludin, J.J. Sela, A. Schroeder, Y. Samuni, D.W. Nitzan, G. Amir

Comparison of load responsiveness of cartilage T1rho and T2 in porcine knee joints: an experimental loading MRI study H. Hamada, T. Nishii, S. Tamura,

Dietary fatty acids differentially affect the development of injury-induced osteoarthritis with diet-induced obesity in mice C.-L. Wu, D. Jain, D. Little,

Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage T.N.

Cyclodextrin polysulphate protects articular cartilage in experimental lapine knee osteoarthritis S. Groeneboer, M.Sc., P. Pastoureau, M.D., Ph.D., E.

Site-dependent changes in structure and function of lapine articular cartilage 4 weeks after anterior cruciate ligament transection J.T.A. Mäkelä, Z.S.

M. A. McNulty, R. F. Loeser, C. Davey, M. F. Callahan, C. M

Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis R.E. Miller, P.B. Tran,

K.H. Collins, R.A. Reimer, R.A. Seerattan, T.R. Leonard, W. Herzog

Knee Images Digital Analysis (KIDA): a novel method to quantify individual radiographic features of knee osteoarthritis in detail A.C.A. Marijnissen,

Quantitative MR T2 measurement of articular cartilage to assess the treatment effect of intra-articular hyaluronic acid injection on experimental osteoarthritis.

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the dog J.L. Cook, K. Kuroki, D. Visco, J.-P.

Effect of muscle weakness and joint inflammation on the onset and progression of osteoarthritis in the rabbit knee C. Egloff, A. Sawatsky, T. Leonard,

Evidence for articular cartilage regeneration in MRL/MpJ mice

In early OA, thinning of the subchondral plate is directly related to cartilage damage: results from a canine ACLT-meniscectomy model F. Intema, H.A.W.

Joint instability leads to long-term alterations to knee synovium and osteoarthritis in a rabbit model C. Egloff, D.A. Hart, C. Hewitt, P. Vavken, V.

Articular damage caused by metal plugs in a rabbit model for treatment of localized cartilage defects R.J.H. Custers, M.D., W.J.A. Dhert, M.D., Ph.D.,

Significance of the serum CTX-II level in an osteoarthritis animal model: a 5-month longitudinal study M.E. Duclos, O. Roualdes, R. Cararo, J.C. Rousseau,

Who should have a joint replacement? A plea for more ‘phronesis’

Intra-articular hyaluronate in experimental rabbit osteoarthritis can prevent changes in cartilage proteoglycan content1 1 Supported by the Department.

Arjen B. Blom, Ph. D. , Peter L. E. M. van Lent, Ph. D. , Astrid E. M

Osteoarthritis severity is sex dependent in a surgical mouse model

Matrix-associated autologous chondrocyte transplantation in a compartmentalized early stage of osteoarthritis M. Schinhan, M. Gruber, R. Dorotka, M.

Skin pentosidine in very early hip/knee osteoarthritis (CHECK) is not a strong independent predictor of radiographic progression over 5 years follow-up

Quantitative pre-clinical screening of therapeutics for joint diseases using contrast enhanced micro-computed tomography N.J. Willett, T. Thote, M. Hart,

Weight-bearing asymmetry and vertical activity differences in a rat model of post- traumatic knee osteoarthritis C.B. Hamilton, M.A. Pest, V. Pitelka,

The canine ‘groove’ model of osteoarthritis is more than simply the expression of surgically applied damage Simon C. Mastbergen, M.Sc., Anne C. Marijnissen,

A. Sophocleous, A.E. Börjesson, D.M. Salter, S.H. Ralston

Correlation between the MR T2 value at 4

Osteoarthritis year 2012 in review: biology

Osteoarthritis and Cartilage

Osteoarthritis and Cartilage

H. Stenhamre, M. Sc. , K. Slynarski, M. D. , Ph. D. , C. Petrén, T

Transcriptional profiling and pathway analysis of monosodium iodoacetate-induced experimental osteoarthritis in rats: relevance to human disease R.A.

Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression S.L. Bevill, P.L. Briant, M.E. Levenston,

Enhanced cell-induced articular cartilage regeneration by chondrons; the influence of joint damage and harvest site L.A. Vonk, T.S. de Windt, A.H.M.

Presentation transcript:

Degeneration, inflammation, regeneration, and pain/disability in dogs following destabilization or articular cartilage grooving of the stifle joint L.N. Frost-Christensen, D.V.M., S.C. Mastbergen, Ph.D., M.E. Vianen, B.Sc., A. Hartog, J. DeGroot, Ph.D., G. Voorhout, A.M.C. van Wees, F.P.J.G. Lafeber, Ph.D., H.A.W. Hazewinkel, D.V.M., Ph.D. Osteoarthritis and Cartilage Volume 16, Issue 11, Pages 1327-1335 (November 2008) DOI: 10.1016/j.joca.2008.03.013 Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Mean overall osteophyte formation scores (±s.e.m.) over time from the predefined locations on the medio-lateral view (black and hatched) and the posterior–anterior (grey and white) view, for the ACLT–MX- (black and grey bars) and the Groove-model (hatched and white bars). There was a significant (P<0.05) increase in the overall osteophyte score from week 4 till week 12 in the Groove-model and from week 0 till week 12 for the ACLT–MX-model. The ACLT–MX-model had at all time points a significant (P<0.05) higher score than the Groove-model. No osteophytes were found in control joints at any time of the study (not shown). Osteoarthritis and Cartilage 2008 16, 1327-1335DOI: (10.1016/j.joca.2008.03.013) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Percentage difference from the baseline of the peak GRFs: braking (A), vertical stance (B) and propelling forces (C) of the hind legs in dogs of the ACLT–MX- and the Groove-model. Mean values (±s.e.m.) are given. Asterisk indicates significant (P<0.05) difference from the baseline value for each leg individually. For the experimental joints the ACLT–MX-model was at all time points statistically significant (P<0.05) different from the Groove-model. Osteoarthritis and Cartilage 2008 16, 1327-1335DOI: (10.1016/j.joca.2008.03.013) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Cartilage integrity in ACLT–MX- and Groove-model. Mean values (±s.e.m.) of the absolute change (Δ) are given for cartilage macroscopic (A) and histologic (B) scores and the percentage change (%) of the control joint for the proteoglycan content (C) for the femoral condyles and tibial plateau. Changes for both models, the ACLT–MX- (light grey) and the Groove-model (dark grey) are depicted. Asterisk indicates a significant (P<0.05) difference between the experimental joint and the contra-lateral control joint. P Values for the difference between the ACLT–MX- and the Groove-model are given in the figure. Osteoarthritis and Cartilage 2008 16, 1327-1335DOI: (10.1016/j.joca.2008.03.013) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Chondrocyte activity in ACLT–MX- and Groove-model. Mean values (±s.e.m.) of the percentage change (%) of the control joint are given for proteoglycan synthesis (A) and percentage of total proteoglycan release (B) for the femoral condyles and tibial plateau in the ACLT–MX- (light grey) and the Groove-model (dark grey). Asterisk indicates a significant (P<0.05) difference between the experimental joint and the contra-lateral control joint. P Values for the difference between the ACLT–MX- and the Groove-model are given in the figure. Osteoarthritis and Cartilage 2008 16, 1327-1335DOI: (10.1016/j.joca.2008.03.013) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Inflammatory response in ACLT–MX- and Groove-model. Mean values (±s.e.m.) of the absolute change (Δ) are given for macroscopic (A) and histological (B) scores of the synovial membrane for the femoral condyles and tibial plateau in the ACLT–MX- (light grey) and the Groove-model (dark grey). Asterisk indicates a significant (P<0.05) difference between the experimental joint and the contra-lateral control joint. P Values for the difference between the ACLT–MX- and the Groove-model are given in the figure. Osteoarthritis and Cartilage 2008 16, 1327-1335DOI: (10.1016/j.joca.2008.03.013) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions