(A) Fractional probability of target attainment (expressed as a percentage) of intravenous levofloxacin at 500 mg daily, based on PK in healthy volunteers.

Slides:

Advertisements

Similar presentations

Table 3 Clinical response success rate, according to prior effective antimicrobial therapy in hospitalized patients with community-acquired pneumonia given.

Advertisements

Table 5 Sample format for results of Streptococcus pneumoniae isolate testing in a laboratory that routinely performs only oxacillin disk tests for penicillin.

Grepafloxacin: microbiological properties

European perspective and update on the management of nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus after more than 10 years.

Activity of ciprofloxacin and levofloxacin in experimental pneumonia caused by Klebsiella pneumoniae deficient in porins, expressing active efflux and.

The role of fourth-generation cephalosporins in the treatment of infections caused by penicillin-resistant streptococci Keith Klugman, Fred Goldstein,

Fourth-generation cephalosporins: a review of in vitro activity, pharmacokinetics, pharmacodynamics and clinical utility Javier Garau, Walter Wilson,

Pharmacodynamic comparison of linezolid, teicoplanin and vancomycin against clinical isolates of Staphylococcus aureus and coagulase-negative staphylococci.

Negative stain of an enveloped virus with such short surface projections that they are not often visible in negative stains (rubella virus); the nucleocapsids.

Elements of design: the knowledge on which we build

M.R. Jacobs Clinical Microbiology and Infection

Levofloxacin in the treatment of ventilator-associated pneumonia

Building in efficacy: developing solutions to combat drug‐resistant S

Voriconazole tissue and fluid concentrations in humans as multiples of the maximal or simultaneously measured concentration in plasma (μg/ml) after systemic.

Cross section of the brain of a mouse with cryptococcal meningoencephalitis. Cross section of the brain of a mouse with cryptococcal meningoencephalitis.

Functional range and environmental niches of the Pseudomonas genus, highlighting the broad distribution of the P. fluorescens species complex. Functional.

MIC distributions of selected β-lactam antimicrobial agents for H

Addressing resistance evolution in Pseudomonas aeruginosa using pharmacodynamic modelling: application to meropenem dosage and combination therapy L.

Agents of notifiable infectious diseases and their associated data often travel through layers of agencies, including clinics, laboratories, and public.

J. Garau Clinical Microbiology and Infection

Grepafloxacin: pharmacokinetics and tissue penetration

Pathogenic schemes of diarrheagenic E. coli.

Phylogenetic tree constructed by the neighbor-joining method, showing the position of Peptostreptococcus species within Clostridium rRNA clusters XI, XIII,

Evolving problems with resistant pathogens

Phylogenetic tree showing generic and species positions based on Bayesian analysis of the nuclear ribosomal DNA 28S region (1,200 bp) of Schistosomatidae.

Statistical characterisation of bacterial wild-type MIC value distributions and the determination of epidemiological cut-off values J. Turnidge, G. Kahlmeter,

Reducing antibiotic use in influenza: challenges and rewards

Etest MBL strip (reprinted with permission from AB BIODISK, Solna, Sweden) and an Acinetobacter sp. expressing a VIM-2 MBL. The intersection of the ellipses.

Circulation of international clones of levofloxacin non-susceptible Streptococcus pneumoniae in Taiwan Y.-C. Hsieh, L.-Y. Chang, Y.-C. Huang, H.-C. Lin,

Species diversity within the P. fluorescens species complex.

Carbapenemase-producing Klebsiella pneumoniae: (when) might we still consider treating with carbapenems? G.L. Daikos, A. Markogiannakis Clinical Microbiology.

Approximate numbers of cases per 100,000 individuals caused by penicillin resistance for each year (left). Approximate numbers of cases per 100,000 individuals.

Biphasic nature of leptospirosis and relevant investigations at different stages of disease. Biphasic nature of leptospirosis and relevant investigations.

Comparative analysis of C. glabrata, C. albicans, and S

Phylogenetic tree of MRSA strains.

Bactericidal effect of probiotic L

Proportions of patients with not serious, serious, or fatal disease with a diagnosis of P. falciparum or P. vivax infection and having parasitemias of.

Increasing prevalence of multidrug resistance among P

Diagram of the group A streptococcal cell covered with an outer hyaluronic acid capsule and the group A carbohydrate, consisting of a polymer of rhamnose.

Transmission electron micrograph of M

Number of outbreaks associated with drinking water by water system type and year (n = 780), 1971 to “Other” includes outbreaks associated with bottled.

Percentages of outbreak deficiencies (n = 671) in public water systems (n = 656) by time period, 1971 to 2006, excluding outbreaks associated with Legionella.

G. Kahlmeter Clinical Microbiology and Infection

High-resolution scanning electron microscopy.

(Top) Graph illustrating citations in books for Plasmodium falciparum and Plasmodium vivax from 1900 to 2008, generated by use of the tool at

Periprosthetic knee joint infection of a patient with a history of clinical and infectious laboratory parameters for 2 weeks. Periprosthetic knee joint.

Summary of the distribution and genetic context of the OXA-type enzymes in Acinetobacter baumannii. Summary of the distribution and genetic context of.

The type strain of H. pittmaniae was cultured for 24 h on different agars in the presence of a NAD-containing disk and photographed by transillumination.

Fabrizio Dutly, and Martin Altwegg Clin. Microbiol. Rev. 2001; doi:10

Human subcutaneous and ocular dirofilariasis.

Plasmodium knowlesi infections reported in humans and macaques and limits of natural distribution of mosquito vectors and of macaques. Plasmodium knowlesi.

Clinical manifestations of bejel.

Publications on biosensors for the field in general compared with the specific detection of whole bacteria. Publications on biosensors for the field in.

World map showing the distribution areas of Trichinella spiralis (Tsp), Trichinella pseudospiralis from north America (TpsN), T. pseudospiralis from Europe.

Membrane-associated proteins expressed by human epithelial cells that function as receptors for Afa/Dr adhesins. Membrane-associated proteins expressed.

Data from an active surveillance study performed in Ohio in 1991, showing age-specific rates of community-acquired pneumonia due to the major bacterial.

Schematic representation of a rotavirus virion.

Human-bovine rotavirus reassortant vaccine (RotaTeq).

(A) T. vaginalis parasite as seen in broth culture.

Fluconazole zone diameter distributions for all Candida spp

Adherence patterns of enteropathogenic E

Correlation of HIV-1 replication fitness, as measured by the Monogram Biosciences RC assay, with baseline CD4+ T-cell count (a) and baseline plasma HIV-1.

Pathology of acute human Chagas' disease.

(A to E) Scanning electron micrographs of S

Relationship between MIC, dose of fluconazole, and emergence/expression of specific resistance mechanisms in oropharyngeal candidiasis. •, MIC of fluconazole.

Mechanism of molecular transport from serum into salivary gland ducts.

Distribution of the four major molecular types of C

Kaplan-Meier analysis of mice treated with rifampin (dashed line) and ceftriaxone (solid line) for experimental S. pneumoniae meningitis. Kaplan-Meier.

Mussels. Mussels. Massive mussel mortality due to Capronia (a member of Chaetothyriales)-like black yeast infection is shown. (Reproduced from reference.

Transmission electron micrographs of epithelial respiratory cells exposed to S. maltophilia CF 1 (A) and NCF 13 (B) for 3 h. Transmission electron micrographs.

Presentation transcript:

(A) Fractional probability of target attainment (expressed as a percentage) of intravenous levofloxacin at 500 mg daily, based on PK in healthy volunteers. (A) Fractional probability of target attainment (expressed as a percentage) of intravenous levofloxacin at 500 mg daily, based on PK in healthy volunteers. (Generated using data from reference 22.) (B) Fractional probability of target attainment of intravenous levofloxacin at 750 mg daily, based on PK in a clinical efficacy study, compared to MIC distributions of two major nosocomial pneumonia pathogens. (Reprinted from reference 59 with permission. © 2004 by the Infectious Diseases Society of America. All rights reserved.)‏ John Turnidge, and David L. Paterson Clin. Microbiol. Rev. 2007; doi:10.1128/CMR.00047-06