Improved left ventricular unloading and circulatory support with synchronized pulsatile left ventricular assistance compared with continuous-flow left.

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Presentation transcript:

Improved left ventricular unloading and circulatory support with synchronized pulsatile left ventricular assistance compared with continuous-flow left ventricular assistance in an acute porcine left ventricular failure model George V. Letsou, MD, Thomas D. Pate, MS, Jeffrey R. Gohean, MS, Mark Kurusz, BA, CCP, Raul G. Longoria, PhD, Larry Kaiser, MD, Richard W. Smalling, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 140, Issue 5, Pages 1181-1188 (November 2010) DOI: 10.1016/j.jtcvs.2010.03.043 Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Schematic of the experimental preparation and instrumentation. LVV, Left ventricular volume crystals; LVP, left ventricular pressure micromanometer; QVAD, VAD flow probe; LAP, left atrial pressure catheter; QAo, aortic flow probe; AoP, aortic pressure micromanometer; CVP, central venous pressure catheter. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 1181-1188DOI: (10.1016/j.jtcvs.2010.03.043) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Hemodynamic recordings obtained from pig 14 during baseline (A), with LAD ligation and acute LV failure (B), with TORVAD (Windmill Cardiovascular Systems, Inc, Austin, TX) support during failure (C), and with BioMedicus (Medtronic, Inc, Minneapolis, MN) support during failure (D). AOP, Aortic pressure; LV, left ventricular; LVP, left ventricular pressure; LAP, left atrial pressure; QAO, transaortic valve flow; QVAD, ventricular assist device output. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 1181-1188DOI: (10.1016/j.jtcvs.2010.03.043) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Cardiac output (A), aortic valve flow (B), mean LAP (C), and MAP (D) with LAD ligation during acute LV failure. Measurements were obtained during LV failure after LAD occlusion and then with BioMedicus and TORVAD support in random sequence. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 1181-1188DOI: (10.1016/j.jtcvs.2010.03.043) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Pressure-volume loops obtained from pig 14 during baseline, with LAD ligation and acute LV failure, with BioMedicus support during failure, and with TORVAD support during failure. LV, Left ventricular; LVP, left ventricular pressure; LVV, left ventricular volume. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 1181-1188DOI: (10.1016/j.jtcvs.2010.03.043) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions