James J. Doutch, Andrew J. Quantock, Nancy C. Joyce, Keith M. Meek

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Ultraviolet Light Transmission through the Human Corneal Stroma Is Reduced in the Periphery James J. Doutch, Andrew J. Quantock, Nancy C. Joyce, Keith M. Meek Biophysical Journal Volume 102, Issue 6, Pages 1258-1264 (March 2012) DOI: 10.1016/j.bpj.2012.02.023 Copyright © 2012 Biophysical Society Terms and Conditions

Figure 1 Three-dimensional representation of stromal UV transmission as a function of wavelength and of position from the center of the cornea. The reduction in transmission from center to periphery is apparent at all wavelengths, but is more dramatic at higher wavelengths. Biophysical Journal 2012 102, 1258-1264DOI: (10.1016/j.bpj.2012.02.023) Copyright © 2012 Biophysical Society Terms and Conditions

Figure 2 UV transmission through the stroma as a function of wavelength at different positions from the center of the human cornea (n = 4). At all positions from center to periphery there is an approximately linear dependence between transmission and wavelength. The largest reductions in transmission are seen centrally. (Bars represent standard deviations). Biophysical Journal 2012 102, 1258-1264DOI: (10.1016/j.bpj.2012.02.023) Copyright © 2012 Biophysical Society Terms and Conditions

Figure 3 Corneal light transmission as a function of wavelength, from theoretical calculations of light scattering. Theoretical predictions of scatter from the collagen fibrils alone suggest the same trends as observed experimentally from the cornea as a whole, although the numerical dependencies are different to those seen experimentally (in Figure 2). Biophysical Journal 2012 102, 1258-1264DOI: (10.1016/j.bpj.2012.02.023) Copyright © 2012 Biophysical Society Terms and Conditions

Figure 4 Estimated contribution of scattering (squares) and absorption (triangles) to the measured extinction of UV light (diamonds) at the center and periphery of the cornea. At the corneal periphery, absorption shows negligible wavelength dependence. At the corneal center, however, a negative correlation between absorption and increasing wavelength is apparent so that at the lower limits of the visual spectrum (400 nm) the human cornea absorbs very little light. Biophysical Journal 2012 102, 1258-1264DOI: (10.1016/j.bpj.2012.02.023) Copyright © 2012 Biophysical Society Terms and Conditions