A semi-blinded study comparing 2 methods of measuring nasal potential difference: Subcutaneous needle versus dermal abrasion E. De Wachter, I. De Schutter,

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Presentation transcript:

A semi-blinded study comparing 2 methods of measuring nasal potential difference: Subcutaneous needle versus dermal abrasion E. De Wachter, I. De Schutter, A. Meulemans, R. Buyl, A. Malfroot Journal of Cystic Fibrosis Volume 15, Issue 1, Pages 60-66 (January 2016) DOI: 10.1016/j.jcf.2015.06.007 Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 2 NPD set-ups: (A) Subcutaneous needle method (Ndl) with the Ringer-agar filled butterfly needle in the fore-arm, connected to the calomel electrode in a 3M KCl container; and (B) dermal abrasion method (Abr), with the Ag/AgCl electrode fixed on an abraded area of the fore-arm and connection of the Ag/AgCl electrode with the ECG-Ringer filled nasal catheter in a 50mL syringe. Journal of Cystic Fibrosis 2016 15, 60-66DOI: (10.1016/j.jcf.2015.06.007) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 Detailed results of NPD tracings in CF and HV with Ndl and Abr method, regarding: Wilschanski score, Sermet score and total chloride response. Each dot represents the calculated Wils score (A), Ser score (B) and total chloride response (C) for each NPD test performed with Ndl and Abr method in CF and HV. Error bars indicate mean (●) and 95% confidence interval. Dotted lines represent the cut-off value for each parameter for CF-diagnosis: Wils score ≤0.7mV; Ser score ≥0.27; total chloride response <−10mV, (Δ) represents inconsistent results (total chloride): 1 CF with Abr, 2 HV with Ndl and 1 HV with Abr. Journal of Cystic Fibrosis 2016 15, 60-66DOI: (10.1016/j.jcf.2015.06.007) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions