A new method for quantification of false lumen thrombosis in aortic dissection using magnetic resonance imaging and a blood pool contrast agent Rachel.

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Presentation transcript:

A new method for quantification of false lumen thrombosis in aortic dissection using magnetic resonance imaging and a blood pool contrast agent Rachel E. Clough, MB, BS, BSc, Tarique Hussain, MA, MB, BChir, Sergio Uribe, PhD, Gerald F. Greil, MD, Reza Razavi, MB, BS, MD, Peter R. Taylor, MA, MChir, Tobias Schaeffter, PhD, Matthew Waltham, MA, PhD Journal of Vascular Surgery Volume 54, Issue 5, Pages 1251-1258 (November 2011) DOI: 10.1016/j.jvs.2011.05.022 Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 1 Bland-Altman plot illustrating the difference in thrombus volume derived from first pass computed tomography (CT) and magnetic resonance imaging (MRI). Good agreement between the two techniques is demonstrated with no proportional bias. Journal of Vascular Surgery 2011 54, 1251-1258DOI: (10.1016/j.jvs.2011.05.022) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 2 In all patients, the volume of thrombus derived from first pass acquisitions was greater than the volume derived from delayed phase magnetic resonance imaging (MRI) with blood pool agent. The first pass acquisitions overestimated the volume of thrombus by an average of six times. CT, Computed tomography. Journal of Vascular Surgery 2011 54, 1251-1258DOI: (10.1016/j.jvs.2011.05.022) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 3 First pass images and delayed phase magnetic resonance (MR) images with blood pool agent demonstrating marked difference in contrast enhancement of the false lumen. (i) A, First pass computed tomography (CT); B, corresponding delayed phase MR image with blood pool agent. (ii) A, First pass MR; B, corresponding delayed phase MR image with blood pool agent. Journal of Vascular Surgery 2011 54, 1251-1258DOI: (10.1016/j.jvs.2011.05.022) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 4 The difference in thrombus volume between first pass and delayed phase magnetic resonance imaging (MRI) with blood pool agent correlated significantly with the mean velocity of flow in the false lumen, with lower flow related to a greater difference. Journal of Vascular Surgery 2011 54, 1251-1258DOI: (10.1016/j.jvs.2011.05.022) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 5 Areas of thrombus enhancement on DTI were segmented to create a mask, and this was aligned with the delayed phase MR blood pool image data using the global scan coordinates. In all patients, the area of thrombus on direct thrombus images matched the area of contrast absence on delayed phase magnetic resonance (MR) with blood pool agent. A, Direct thrombus image; B, thrombus segmented; C, mask; D, delayed phase MR image with blood pool agent; E, mask from image B aligned with image D using the global scan coordinates. *Area of thrombus. Journal of Vascular Surgery 2011 54, 1251-1258DOI: (10.1016/j.jvs.2011.05.022) Copyright © 2011 Society for Vascular Surgery Terms and Conditions