Possible role of TH17 cells in the pathogenesis of Stevens-Johnson syndrome and toxic epidermal necrolysis Yuichi Teraki, MD, Misaki Kawabe, MD, Seiichi.

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Presentation transcript:

Possible role of TH17 cells in the pathogenesis of Stevens-Johnson syndrome and toxic epidermal necrolysis Yuichi Teraki, MD, Misaki Kawabe, MD, Seiichi Izaki, MD Journal of Allergy and Clinical Immunology Volume 131, Issue 3, Pages 907-909 (March 2013) DOI: 10.1016/j.jaci.2012.08.042 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, The proportions of cytokine-producing circulating T cells in patients with SJS/TEN, patients with EMM, and healthy subjects. B, A significantly higher proportion of IL-17+CD4+ T cells is observed in the CLA+CCR4+ subset in patients with SJS/TEN. C, The proportions of cytokine-producing T cells in the circulation and blister fluid of patients with SJS/TEN. D, Correlation between the proportion of IL-17+CD4+ T cells in blister fluid and the severity of SJS/TEN. Journal of Allergy and Clinical Immunology 2013 131, 907-909DOI: (10.1016/j.jaci.2012.08.042) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 The proportion of circulating IL-17+CD4+ T cells significantly decreased after improvement of SJS/TEN. Journal of Allergy and Clinical Immunology 2013 131, 907-909DOI: (10.1016/j.jaci.2012.08.042) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions