Presence of Epstein–Barr Virus in Langerhans Cells of CTCL Lesions

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Presentation transcript:

Presence of Epstein–Barr Virus in Langerhans Cells of CTCL Lesions A.C. Knol, G. Quéreux, M.C. Pandolfino, A. Khammari, B. Dreno Journal of Investigative Dermatology Volume 124, Issue 1, Pages 280-282 (January 2005) DOI: 10.1111/j.0022-202X.2004.23570.x Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Detection of Epstein–Barr virus (EBV) in the cutaneous lesions and in the blood of cutaneous T cell lymphoma (CTCL) patients. Single staining of immunofluorescence with monoclonal EBNA2 antibody on cutaneous sections of lesional skin in CTCL (A). Double staining of immunofluorescence with CD1a monoclonal antibody (red, B) and monoclonal anti-EBNA2 on cutaneous sections of lesional skin in CTCL (green, C). The combined immunochemistry (CD1a monoclonal antibody) hybridization technique (EBER1 PNA probe) revealed CD1a-positive cells (red–brown color) with EBER RNA (nuclear dark-blue color) in epidermis (magnification × 40; 7 mm on scale bar represents 175 μm) (D). RT-PCR analysis of blood Vβ T cell clone RNA, note the absence of the virus (E). Journal of Investigative Dermatology 2005 124, 280-282DOI: (10.1111/j.0022-202X.2004.23570.x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions