Morphological and compositional monitoring of a new cell-free cartilage repair hydrogel technology – GelrinC by MR using semi-quantitative MOCART scoring.

Slides:

Advertisements

Similar presentations

Functional ankle instability as a risk factor for osteoarthritis: using T2-mapping to analyze early cartilage degeneration in the ankle joint of young.

Advertisements

Whole joint MRI assessment of surgical cartilage repair of the knee: Cartilage Repair OsteoArthritis Knee Score (CROAKS) F.W. Roemer, A. Guermazi, S.

Microstructural remodeling of articular cartilage following defect repair by osteochondral autograft transfer C.B. Raub, S.C. Hsu, E.F. Chan, R. Shirazi,

Validity and responsiveness of a new measure of knee osteophytes for osteoarthritis studies: data from the osteoarthritis initiative M. Hakky, M. Jarraya,

Single-stage cell-based cartilage repair in a rabbit model: cell tracking and in vivo chondrogenesis of human umbilical cord blood-derived mesenchymal.

Implantation of bone marrow-derived buffy coat can supplement bone marrow stimulation for articular cartilage repair L.H. Jin, B.H. Choi, Y.J. Kim, S.R.

A. Guermazi, H. Alizai, M. D. Crema, S. Trattnig, R. R. Regatte, F. W

J. K. Meckes, B. Caramés, M. Olmer, W. B. Kiosses, S. P. Grogan, M. K

Imaging following acute knee trauma

2D and 3D MOCART scoring systems assessed by 9

Changes in the T2 relaxation value of the tibiofemoral articular cartilage about 6 months after anterior cruciate ligament reconstruction using the double-bundle.

Considerations in measuring cartilage thickness using MRI: factors influencing reproducibility and accuracy S. Koo, M.S., G.E. Gold, M.D., T.P. Andriacchi,

Multimodal approach in the use of clinical scoring, morphological MRI and biochemical T2-mapping and diffusion-weighted imaging in their ability to assess.

Microstructural remodeling of articular cartilage following defect repair by osteochondral autograft transfer C.B. Raub, S.C. Hsu, E.F. Chan, R. Shirazi,

T. Maerz, M. D. Newton, K. Kristof, O. Motovylyak, J. S. Fischgrund, D

T1ρ and T2 relaxation times predict progression of knee osteoarthritis

Articular chondrocytes derived from distinct tissue zones differentially respond to in vitro oscillatory tensile loading E.J. Vanderploeg, Ph.D., C.G.

A. Williams, Y. Qian, D. Bear, C.R. Chu Osteoarthritis and Cartilage

C. Shi, G.J. Wright, C.L. Ex-Lubeskie, A.D. Bradshaw, H. Yao

C. D. Jordan, E. J. McWalter, U. D. Monu, R. D. Watkins, W. Chen, N. K

Evaluation of native hyaline cartilage and repair tissue after two cartilage repair surgery techniques with 23Na MR imaging at 7 T: initial experience

In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis N.H. Lim, E. Meinjohanns, M. Meldal, G.

Evaluation of cartilage matrix disorders by T2 relaxation time in patients with hip dysplasia T. Nishii, M.D., H. Tanaka, M.D., N. Sugano, M.D., T. Sakai,

Imaging of non-osteochondral tissues in osteoarthritis

Osteoarthritis and Cartilage

Three-dimensional hip cartilage quality assessment of morphology and dGEMRIC by planar maps and automated segmentation C. Siversson, A. Akhondi-Asl,

Intraoperative validation of quantitative T2 mapping in patients with articular cartilage lesions of the knee S.T. Soellner, A. Goldmann, D. Muelheims,

Experimental scoring systems for macroscopic articular cartilage repair correlate with the MOCART score assessed by a high-field MRI at 9.4 T – comparative.

Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice S. Hashimoto, M.F. Rai, K.L.

Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis X. Wang, F. Cicuttini, X. Jin,

Evaluation of cartilage repair in the distal femur after autologous chondrocyte transplantation using T2 relaxation time and dGEMRIC J.E. Kurkijärvi,

Positron emission tomography with 18F-FDG in osteoarthritic knee

A longitudinal study of the quantitative evaluation of patella cartilage after total knee replacement by delayed gadolinium-enhanced magnetic resonance.

The effect of anterior cruciate ligament injury on bone curvature: exploratory analysis in the KANON trial D.J. Hunter, L.S. Lohmander, J. Makovey, J.

X. Zhu, Y. Tang, J. Chen, S. Xiong, S. Zhuo, J. Chen

H. Shao, C. Pauli, S. Li, Y. Ma, A. S. Tadros, A. Kavanaugh, E. Y

L. A. MacFarlane, H. Yang, J. E. Collins, A. Guermazi, M. H. Jones, E

B. Bittersohl, F. R. Miese, H. S. Hosalkar, M. Herten, G. Antoch, R

C.P. Neu Osteoarthritis and Cartilage

Pre-operative interventions (non-surgical and non-pharmacological) for patients with hip or knee osteoarthritis awaiting joint replacement surgery – a.

Whole joint MRI assessment of surgical cartilage repair of the knee: Cartilage Repair OsteoArthritis Knee Score (CROAKS) F.W. Roemer, A. Guermazi, S.

G. Venne, S. Pang, Y. Tse, R. Ellis Osteoarthritis and Cartilage

Exercise intervention increases expression of bone morphogenetic proteins and prevents the progression of cartilage-subchondral bone lesions in a post-traumatic.

P. -H. Tsai, M. -C. Chou, H. -S. Lee, C. -H. Lee, H. -W. Chung, Y. -C

Synovial volume vs synovial measurements from dynamic contrast enhanced MRI as measures of response in osteoarthritis A.D. Gait, R. Hodgson, M.J. Parkes,

Hyaluronic acid hydrogel functionalized with self-assembled micelles of amphiphilic pegylated kartogenin for the treatment of osteoarthritis M.-L. Kang,

Residual hip dysplasia at 1 year after treatment for neonatal hip instability is not related to degenerative joint disease in young adulthood: a 21-year.

Stem cell therapy for human cartilage defects: a systematic review

R. Lattanzi, C. Petchprapa, D. Ascani, J. S. Babb, D. Chu, R. I

MRI morphological and quantitative evaluation of knee allograft repair at 3, 6 and 9 months post-op: early surveillance demonstrates nascent physiological.

Patterns of joint damage seen on MRI in early hip osteoarthritis due to structural hip deformities D. Stelzeneder, T.C. Mamisch, I. Kress, S.E. Domayer,

Development of quantitative in vivo imaging of articular cartilage degradation in murine osteoarthritis P. Das Neves Borges, M.M. Fowkes, P.E. Brennan,

Changes in biomechanical risk factors for knee osteoarthritis and their association with 5-year clinically important improvement after limb realignment.

Baseline radiographic osteoarthritis and semi-quantitatively assessed meniscal damage and extrusion and cartilage damage on MRI is related to quantitatively.

F.W. Roemer, M.D. Osteoarthritis and Cartilage

Functional ankle instability as a risk factor for osteoarthritis: using T2-mapping to analyze early cartilage degeneration in the ankle joint of young.

P. Kang, Y. Yao, J. Yang, B. Shen, Z. Zhou, F. Pei

Three dimensional distribution of hip cartilage t2 mapping assessed by radial mr imaging: comparison between healthy volunteers and patients with hip.

T2 assessment and clinical outcome following autologous matrix-assisted chondrocyte and osteochondral autograft transplantation G.M. Salzmann, J. Paul,

Long-term results 8 years after autologous osteochondral transplantation: 7 T gagCEST and sodium magnetic resonance imaging with morphological and clinical.

Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis D.H. Rosenzweig,

A new method to analyze dGEMRIC measurements in femoroacetabular impingement: preliminary validation against arthroscopic findings R. Lattanzi, C. Petchprapa,

Osteoarthritis year 2012 in review: biology

Detection of degenerative cartilage disease: comparison of high-resolution morphological MR and quantitative T2 mapping at 3.0 Tesla S. Apprich, G.H.

Amyloid micronetworks for cartilage repair

Effects of helium–neon laser on the mucopolysaccharide induction in experimental osteoarthritic cartilage Y.-S. Lin, M.Sc, Dr M.-H. Huang, M.D., Ph.D.,

Cartilage repair of the ankle: first results of T2 mapping at 7

High resolution T1ρ mapping of human knee cartilage at 7T

M. Doherty, P. Dieppe Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Presentation transcript:

Morphological and compositional monitoring of a new cell-free cartilage repair hydrogel technology – GelrinC by MR using semi-quantitative MOCART scoring and quantitative T2 index and new zonal T2 index calculation S. Trattnig, K. Ohel, V. Mlynarik, V. Juras, S. Zbyn, A. Korner Osteoarthritis and Cartilage Volume 23, Issue 12, Pages 2224-2232 (December 2015) DOI: 10.1016/j.joca.2015.07.007 Copyright © 2015 The Authors Terms and Conditions

Fig. 1 Series of proton density fat suppressed images in coronal plane show development of cartilage transplant in follow-up examinations. Arrows and circle delineate RT area. Osteoarthritis and Cartilage 2015 23, 2224-2232DOI: (10.1016/j.joca.2015.07.007) Copyright © 2015 The Authors Terms and Conditions

Fig. 2 T2 index development at 12, 18 and 24 months after surgery using an early post-surgery (1 week) measurement as a reference. A 95% CI as a measure of uncertainty is indicated. Osteoarthritis and Cartilage 2015 23, 2224-2232DOI: (10.1016/j.joca.2015.07.007) Copyright © 2015 The Authors Terms and Conditions

Fig. 3 An example of T2 zonal evaluation. Superficial and deep ROIs for cartilage transplant tissue (posterior aspect on the image) and normal healthy cartilage (anterior aspect of the image) are shown. Osteoarthritis and Cartilage 2015 23, 2224-2232DOI: (10.1016/j.joca.2015.07.007) Copyright © 2015 The Authors Terms and Conditions

Fig. 4 Change of T2-standard deviations among the pixels of the ROIs drawn on the RT in post-surgery period. The numbers in brackets indicate number of ROIs included. As a reference a standard deviation of healthy tissue was used. Osteoarthritis and Cartilage 2015 23, 2224-2232DOI: (10.1016/j.joca.2015.07.007) Copyright © 2015 The Authors Terms and Conditions

Fig. 5 Image examples of morphological (left column) and T2 mapping (right column) of the post-surgery period are shown. Cartilage in T2 maps is pseudo-colored for better visualization. Color-bar is added for T2 map quantification. Osteoarthritis and Cartilage 2015 23, 2224-2232DOI: (10.1016/j.joca.2015.07.007) Copyright © 2015 The Authors Terms and Conditions