Central cholinergic depletion induced by 192 IgG-Saporin alleviates the sedative effects of propofol in rats L. Pain, H. Jeltsch, O. Lehmann, C. Lazarus,

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Central cholinergic depletion induced by 192 IgG-Saporin alleviates the sedative effects of propofol in rats L. Pain, H. Jeltsch, O. Lehmann, C. Lazarus, F.Z. Laalou, J.C. Cassel British Journal of Anaesthesia Volume 85, Issue 6, Pages 869-873 (December 2000) DOI: 10.1093/bja/85.6.869 Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

Fig 1 Sedative potency of propofol 30 mg kg−1 i.p. (T1: 10–15 min, T2: 15–20 min, T3: 20–25 min, after the injection) in rats who received intraventricular injections of 2 μg of 192 IgG-Saporin (SAPO) or of 2 μl of phosphate-buffered saline solution (SHAM). Sedative potency was expressed as the ratio: (activity score after vehicle injection minus activity score after propofol injection)/(activity score after vehicle injection plus activity score after propofol injection). Results are expressed as mean±sem. British Journal of Anaesthesia 2000 85, 869-873DOI: (10.1093/bja/85.6.869) Copyright © 2000 British Journal of Anaesthesia Terms and Conditions