Fig. 4. Irisin protected against oxidative stress and apoptosis in IR-injured lung tissue. Irisin protected against oxidative stress and apoptosis in IR-injured.

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Fig. 4. Irisin protected against oxidative stress and apoptosis in IR-injured lung tissue. Irisin protected against oxidative stress and apoptosis in IR-injured lung tissue. (A) Immunostaining showed that irisin was detected in the mouse lung tissue after IR injury with irisin treatment but not in sham-operated animals (scale bars, 50 μm). (B) Lung tissue sections were immunostained for irisin (green) and AT1a (red, alveolar type I epithelial cell marker) (scale bars, 20 μm). (C) The extent of reactive oxygen species (ROS) production in mouse lung tissue was determined by dihydroethidium staining (*P < 0.05 versus sham group and #P < 0.05 versus IR group; n = 5; scale bars, 100 μm). (D) Assessment of cytochrome c (cyc c) in mitochondria and cytosol derived from lung tissue subjected to IR (*P < 0.05 versus sham and #P < 0.05 versus IR; n = 4). COX IV, cyclooxygenase IV; GAPDH, glyceraldehyde-3-phosphate dehydrogenase. (E) Caspase 9 activation in lung tissue subjected to IR (*P < 0.05 versus sham and #P < 0.05 versus IR; n = 4). Ken Chen et al., Sci Transl Med 2017;9:eaao6298 Published by AAAS