Ordinary vibratory angioedema is not generally associated with ADGRE2 mutation Zuotao Zhao, MD, PhD, Sascha Reimann, MD, Shan Wang, MD, Yuhan Wang, MD,

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Presentation transcript:

Ordinary vibratory angioedema is not generally associated with ADGRE2 mutation Zuotao Zhao, MD, PhD, Sascha Reimann, MD, Shan Wang, MD, Yuhan Wang, MD, Torsten Zuberbier, MD Journal of Allergy and Clinical Immunology Volume 143, Issue 3, Pages 1246-1248.e4 (March 2019) DOI: 10.1016/j.jaci.2018.10.049 Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Picture showing the clinical changes with swelling and erythema of 1 representative patient in 3 before and after the provocation test at different time points. B, The palms and serum-histamine (median) content changes in patients with vibratory angioedema/pruritus before and after provocation at different time intervals (n = 3). **P < .01, ***P < .001, time interval: 5 minutes, 15 minutes, 30 minutes vs 0 minute. Journal of Allergy and Clinical Immunology 2019 143, 1246-1248.e4DOI: (10.1016/j.jaci.2018.10.049) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 A, Picture before and after the provocation test showing the clinical changes with swelling and erythema of 1 representative patient in 3. B, Mean palm thickness of control subjects (n = 3) and patients (n = 3) before and after provocation, respectively. *P < .05, patient: before provocation vs after provocation. C, Mean visual analog scale (VAS) score from 0 to 10. Pruritus score of control subjects (n = 3) and patients (n = 3), respectively. *P < .05, control subjects vs patients. Journal of Allergy and Clinical Immunology 2019 143, 1246-1248.e4DOI: (10.1016/j.jaci.2018.10.049) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Serum-histamine content (mean ± SEM) before and after provocation. *P < .05 (paired t test), patient: before provocation vs after provocation (n = 3). Journal of Allergy and Clinical Immunology 2019 143, 1246-1248.e4DOI: (10.1016/j.jaci.2018.10.049) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Vibratory angioedema and pruritus questionnaire in English. Journal of Allergy and Clinical Immunology 2019 143, 1246-1248.e4DOI: (10.1016/j.jaci.2018.10.049) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions