Volume 128, Issue 5, Pages (March 2007)

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Volume 128, Issue 5, Pages 826-828 (March 2007) The Sunny Side of p53 Moshe Oren, Jiri Bartek Cell Volume 128, Issue 5, Pages 826-828 (March 2007) DOI: 10.1016/j.cell.2007.02.027 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 The Role of p53 in Skin Pigmentation In response to UV-induced genotoxic stress, p53 becomes activated in skin keratinocytes and stimulates transcription from the pro-opiomelanocortin (POMC) gene promoter. The POMC precursor polypeptide is then processed into several bioactive products including α-MSH, which, through a paracrine effect on epidermal melanocytes (mediated by the α-MSH receptor MC1R and the melanocytic transcription factor MITF), leads to melanin production and redistribution among skin cells. The release of ACTH (adrenocorticotropic hormone) and the opioid peptide β-endorphin into the blood may relieve inflammation and contribute to sun-seeking behavior. Cell 2007 128, 826-828DOI: (10.1016/j.cell.2007.02.027) Copyright © 2007 Elsevier Inc. Terms and Conditions