Coagulation, fibrinolysis, and cell activation in patients and shed mediastinal blood during coronary artery bypass grafting with a new heparin-coated.

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Presentation transcript:

Coagulation, fibrinolysis, and cell activation in patients and shed mediastinal blood during coronary artery bypass grafting with a new heparin-coated surface Matilda Johnell, BSca, Graciela Elgue, PhDb, Rolf Larsson, PhDb, Anders Larsson, MD, PhDa, Stefan Thelin, MD, PhDc, Agneta Siegbahn, MD, PhDa The Journal of Thoracic and Cardiovascular Surgery Volume 124, Issue 2, Pages 321-332 (August 2002) DOI: 10.1067/mtc.2002.122551 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 CD11b expression on granulocytes before, during, and after the operation in patients. A, Uncoated group with ACT of 480 seconds (open squares) and CHS-coated group with ACT of 480 seconds (filled squares); B, CHS-coated group with low heparin dose and ACT of 300 seconds (open triangles), with high heparin dose and ACT of 600 seconds (filled triangles), and with standard heparin dose and ACT of 480 seconds (filled squares, dotted line). ##P =.008, ACT of 300 seconds versus ACT of 480 seconds. Results are presented as median and 25th-75th percentile. MFI, Mean fluorescence intensity. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 321-332DOI: (10.1067/mtc.2002.122551) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 MPO in plasma before, during, and after the operation in patients. A, Uncoated group with ACT of 480 seconds (open squares) and CHS-coated group with ACT of 480 seconds (filled squares) *P =.05, **P =.04. B, CHS-coated group with low heparin dose and ACT of 300 seconds (open triangles) and with high heparin dose and ACT of 600 seconds (filled triangles) *P =.01, **P =.002. Results are presented as median and 25th-75th percentiles. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 321-332DOI: (10.1067/mtc.2002.122551) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 P-selectin expression on platelets before, during, and after the operation in patients. A, Uncoated group with ACT of 480 seconds (open squares) and CHS-coated group with ACT of 480 seconds (filled squares) *P =.005, **P =.004. B, CHS-coated group with low heparin dose and ACT of 300 seconds (open triangles) and with high heparin dose and ACT of 600 seconds (filled triangle). Results are presented as median and 25th-75th percentiles. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 321-332DOI: (10.1067/mtc.2002.122551) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 F1+2 in plasma before, during, and after the operation in patients. A, Uncoated group with ACT of 480 seconds (open squares) and CHS-coated group with ACT of 480 seconds (filled squares). *P =.05, **P =.02, ***P =.008. B, CHS-coated group with low heparin dose and ACT of 300 seconds (open triangles), high heparin dose and ACT of 600 seconds (filled triangles), and standard heparin dose and ACT of 480 seconds (filled squares, dotted line. *P =.02, ACT of 300 seconds versus ACT of 600 seconds; #P =.03, ACT of 300 seconds versus ACT of 480 seconds; ##P =.005; ###P <.001; ≬P =.004, ACT of 600 seconds versus ACT of 480 seconds; ≬≬P =.008; ≬≬≬P <.001. Results are presented as median and 25th-75th percentiles. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 321-332DOI: (10.1067/mtc.2002.122551) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 PAP in plasma before, during, and after the operation in patients. A, Uncoated group with ACT of 480 seconds (open squares) and CHS-coated group with ACT of 480 seconds (filled squares). *P =.02, **P =.01, ***P =.006. B, CHS-coated group with low heparin dose and ACT of 300 seconds (open triangles), with high heparin dose and ACT of 600 seconds (filled triangles), and with standard heparin dose and ACT of 480 seconds (filled squares, dotted line). *P =.04, ACT of 300 seconds versus ACT of 600 seconds; **P =.01; #P =.03, ACT of 300 seconds versus ACT of 480 seconds; ##P =.01; ###P =.004; ≬P =.01, ACT of 600 seconds versus ACT of 480 seconds; ≬≬P =.004; ≬≬≬P =.001; ≬≬≬≬P <.001. Results are presented as median and 25th-75th percentiles. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 321-332DOI: (10.1067/mtc.2002.122551) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 6 FXIIa-AT in plasma before, during, and after the operation in patients. A, Uncoated group with ACT of 480 seconds (open squares) and CHS-coated group with ACT of 480 seconds (filled squares). B, CHS-coated group with low heparin dose and ACT of 300 seconds (open triangles) and with high heparin dose and ACT of 600 seconds (filled triangles). Results are presented as median and 25th-75th percentiles. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 321-332DOI: (10.1067/mtc.2002.122551) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions