Tamir S. Aldad, B. A. , Nora Rahmani, B. A. , Csaba Leranth, Ph. D

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Presentation transcript:

Bisphenol-A exposure alters endometrial progesterone receptor expression in the nonhuman primate Tamir S. Aldad, B.A., Nora Rahmani, B.A., Csaba Leranth, Ph.D., Hugh S. Taylor, M.D. Fertility and Sterility Volume 96, Issue 1, Pages 175-179 (July 2011) DOI: 10.1016/j.fertnstert.2011.04.010 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) Endometrial PR expression using immunohistochemcial analysis in the nonhuman primate. Progesterone receptor immunostaining was nearly absent in the glands or stroma of control animals. Bisphenol-A treatment had minimal effect on endometrial PR expression. As expected, E2 treatment led to a large increase in both glandular and stromal PR expression. Treatment with the combination of E2 and BPA led to decreased glandular and stromal expression compared with treatment with E2 alone. Representative photomicrographs taken at 400× magnification are shown. (B) Effect of E2 and BPA on endometrial PR protein expression in the nonhuman primate. H-score was used as a semiquantitative measure of PR expression. Estradiol exposure led to a 49-fold increase in glandular PR expression and an 11-fold increase in stromal PR expression compared with vehicle-treated control (∗P<.01). Exposure to a combination of E2 and BPA decreased glandular PR expression to 62% and decreased stromal PR expression to 50% of the H-score obtained in endometrium of animals treated with E2 alone (∗∗P<.01). Fertility and Sterility 2011 96, 175-179DOI: (10.1016/j.fertnstert.2011.04.010) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Total PR and PR-B mRNA expression in Ishikawa cell line after treatment with E2 and/or BPA. Real-time PCR results show that total PR and PR-B expression increased 5.2-fold and 4.1-fold, respectively, in cells treated with E2 compared with control (∗P<.01). PR and PR-B expression increased 1.7 fold and 1.9 fold, respectively, in cells treated with BPA when compared to the control (∗P<.05). Progesterone receptor and PR-B expression decreased to 0.6-fold and 0.7-fold, respectively, in cells treated with a combination of E2 and BPA when compared with those treated with E2 alone (∗∗P<.01 total PR and P<.05 PR-B). Fertility and Sterility 2011 96, 175-179DOI: (10.1016/j.fertnstert.2011.04.010) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions