Protected by a Fox Neuron Volume 98, Issue 1, Pages 3-5 (April 2018)

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Presentation transcript:

Protected by a Fox Neuron Volume 98, Issue 1, Pages 3-5 (April 2018) Diane Lipscombe, Eduardo Javier Lopez-Soto Neuron Volume 98, Issue 1, Pages 3-5 (April 2018) DOI: 10.1016/j.neuron.2018.03.026 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 The RNA Binding Protein Rbfox1 Stabilizes Vamp1/Synaptobrevin1 mRNA in GABAergic Neurons of the Hippocampus The cytoplasmic isoform of Rbfox1 binds to (U)GCAUG motifs in the 3′ untranslated region (UTR) of Vamp1 mRNA. Here we illustrate one of several Rbfox1 binding sites in the 3′ UTR that protects Vamp1 mRNA from miR-9-mediated degradation. Vamp1 is expressed in inhibitory hippocampal neurons, but not excitatory neurons. In the absence of cytoplasmic Rbfox1, miR-9 binds the 3′ UTR of Vamp1 promoting degradation, reducing Vamp1 protein levels and inhibitory synaptic transmission. Schematic is based on findings reported in Vuong et al. (2018). Neuron 2018 98, 3-5DOI: (10.1016/j.neuron.2018.03.026) Copyright © 2018 Elsevier Inc. Terms and Conditions