Dengue Antibody and Zika: Friend or Foe?

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Presentation transcript:

Dengue Antibody and Zika: Friend or Foe? Anna P. Durbin Trends in Immunology Volume 37, Issue 10, Pages 635-636 (October 2016) DOI: 10.1016/j.it.2016.08.006 Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 Antibody-Dependent Enhancement and Neutralization in Flavivirus Infections. Dengue virus infections with distinct serotypes (blue, red) usually lead to the production of serotype-specific antibodies (blue, red). These antibodies can confer protection against the same serotype (green lines) but may enhance infection by other serotypes (red arrow). Serial infections can lead to the production of broadly crossreactive, highly neutralizing antibodies (pink) that confer protection against multiple serotypes. In the case of Zika virus infection, dengue-specific antibodies may do nothing, may lead to enhanced infection of Fcγ receptor-bearing cells, or may protect against infection, depending on the antibody. Broadly crossreactive, highly neutralizing antibodies against dengue also appear to protect against Zika infection. Trends in Immunology 2016 37, 635-636DOI: (10.1016/j.it.2016.08.006) Copyright © 2016 Elsevier Ltd Terms and Conditions