Fig. 3. ERRα is involved in the regulation of OPLAH.

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Fig. 3. ERRα is involved in the regulation of OPLAH. ERRα is involved in the regulation of OPLAH. (A) OPLAH expression in hESC-derived cardiomyocytes exposed to increasing concentrations of XCT-790 (vehicle, n= 6; 1 μM, n= 6; 3 μM, n= 6; 10 μM, n= 4). (B) OPLAH expression in hESC-derived cardiomyocytes exposed to increasing concentration of 4-hydroxytamoxifen (vehicle, n= 5; 1 μM, n= 6; 3 μM, n= 6; 10 μM, n= 5). (C) CellROX analysis of hESC-derived cardiomyocytes exposed to increasing concentrations of XCT-790 (vehicle, n= 48; 1 μM, n= 48; 3 μM, n= 64; 10 μM, n= 39; n indicates technical replicates). (D) ERRα mRNA expression in hESC-derived cardiomyocytes exposed to increasing concentrations of XCT-790 (vehicle, n= 3; 1 μM, n= 6; 3 μM, n= 4; 10 μM, n= 4). (E) Peroxisome proliferator–activated receptor γ coactivator 1α (PGC-1α) mRNA expression in hESC-derived cardiomyocytes exposed to increasing concentrations of XCT-790 (vehicle, n= 4; 1 μM, n= 6; 3 μM, n= 6; 10 μM, n= 3). (F) CellROX analysis of adenoviral-infected H9C2 cells with control or hOPLAH adenoviral vector exposed to increasing concentration of XCT-790 (vehicle, n= 24; 1 μM, n= 24; 3 μM, n= 24; 10 μM, n= 16; n indicates technical replicates). (G) qRT-PCR mRNA expression of ERRα and OPLAH at different stages of development and IR injury [E12, n= 8; E18, n= 11; PP2, n= 7; 4 weeks, n= 3; 20 weeks (sham), n= 3; 20 weeks (IR), n= 3]. CellROX data are presented as fold change of RFU (A.U.) per microgram protein. Data are presented as means ± SEM. *P< 0.05; **P< 0.01; ***P< 0.001; ****P< 0.0001; #P< 0.05; ##P< 0.01; ###P< 0.001, as calculated by Student’s t test or one-way ANOVA. “*” indicates significant difference compared to control, whereas “#” denotes differences between groups other than control. n indicates the number of biological replicates of cell experiments. Atze van der Pol et al., Sci Transl Med 2017;9:eaam8574 Published by AAAS