Prospective study into the value of the automated Elecsys antimüllerian hormone assay for the assessment of the ovarian growing follicle pool Richard.

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Presentation transcript:

Prospective study into the value of the automated Elecsys antimüllerian hormone assay for the assessment of the ovarian growing follicle pool Richard A. Anderson, M.D., Ph.D., Ellen Anckaert, M.D., Ph.D., Ernesto Bosch, M.D., Didier Dewailly, M.D., Cheryl E. Dunlop, M.D., Daniel Fehr, M.D., Luciano Nardo, M.D., Johan Smitz, M.D., Ph.D., Kelton Tremellen, M.D., Ph.D., Barbara Denk, Ph.D., Andrea Geistanger, Ph.D., Martin Hund, Ph.D. Fertility and Sterility Volume 103, Issue 4, Pages 1074-1080.e4 (April 2015) DOI: 10.1016/j.fertnstert.2015.01.004 Copyright © 2015 The Authors Terms and Conditions

Figure 1 The relationships between (A) AFC and (B) AMH with age, with data from each site shown separately in different colors. To get a more structured view of this data among the different centers, the robust Passing-Bablok regression was chosen to exemplify the mean relationship within each center in this plot. Site-specific AFC/AMH and age distributions are shown in the box and whiskers plots, where the lower and upper limits of the boxes show the lower and upper quartile, the line within the box the median, and the whiskers up to 1.5 times the interquartile range. Fertility and Sterility 2015 103, 1074-1080.e4DOI: (10.1016/j.fertnstert.2015.01.004) Copyright © 2015 The Authors Terms and Conditions

Figure 2 ROC curves for classification of (A) low AFC and (B) high AFC, by AMH, FSH, E2 and age. For low AFC, n = 66 patients with AFC ≤7 versus 385 subjects AFC >7. For high AFC, n = 216 subjects with AFC >15 versus 235 patients AFC ≤15. Fertility and Sterility 2015 103, 1074-1080.e4DOI: (10.1016/j.fertnstert.2015.01.004) Copyright © 2015 The Authors Terms and Conditions

Supplemental Figure 1 Distribution of AMH (ng/mL) in different AFC groups for all sites. The P values in the graph refer to t tests of AMH means between the AFC 0–7 and 8–15 group and between the 8–15 and >15 group. Fertility and Sterility 2015 103, 1074-1080.e4DOI: (10.1016/j.fertnstert.2015.01.004) Copyright © 2015 The Authors Terms and Conditions