Endoscopic Imaging of Angiogenesis In Vivo

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Endoscopic Imaging of Angiogenesis In Vivo Alexander Meining, Michael B. Wallace Gastroenterology Volume 134, Issue 4, Pages 915-918 (April 2008) DOI: 10.1053/j.gastro.2008.02.049 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 NBI-/zoom-Imaging of (A) non-neoplastic mucosa of the esophagus and (B) neoplastic squamous mucosa. Note the expansion and irregularity of the intrapapillary capillary loops (IPCL) of the neoplastic tissue. Gastroenterology 2008 134, 915-918DOI: (10.1053/j.gastro.2008.02.049) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 Confocal laser scanning imaging of (A) an adenocarcinoma and (B) of normal colonic mucosa. In tumorous tissue, irregular vessels and fluorescein leakage can be demonstrated in contrast to regular vessels surrounding healthy colonic crypts. (C and D) Respective images with intramucosal microvessels enhanced with a specially designed software. In addition to the length, diameter and area of vessels, the percentage of the vessel area in relation to the image as a whole can objectively be documented. Gastroenterology 2008 134, 915-918DOI: (10.1053/j.gastro.2008.02.049) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 (A) Confocal laser scanning image of a cholangiocarcinoma at the liver hilus. Malignancy is demonstrated by white streaks resembling enlarged irregular tumor vessels. (B) Corresponding histopathologic image of the tumor after resection with CD-31 immunohistochemistry stain demonstrating an increased number of irregular branching vessels (original magnification, ×400). Gastroenterology 2008 134, 915-918DOI: (10.1053/j.gastro.2008.02.049) Copyright © 2008 AGA Institute Terms and Conditions