Effects of selectin–sialyl Lewisx blockade on mesenteric microvascular permeability associated with cardiopulmonary bypass Charles S. Cox, MD, Steven.

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Presentation transcript:

Effects of selectin–sialyl Lewisx blockade on mesenteric microvascular permeability associated with cardiopulmonary bypass Charles S. Cox, MD, Steven J. Allen, MD, Henning Sauer, MD, John Frederick, BS The Journal of Thoracic and Cardiovascular Surgery Volume 119, Issue 6, Pages 1255-1261 (June 2000) DOI: 10.1067/mtc.2000.105262 Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 QL increases with the increase in mesenteric venous pressure. There is no statistical difference in QL between groups after the initiation of CPB. *Statistical significance with respect to wash down in control group (P = .02 at 30 minutes of CPB compared with wash down). The Journal of Thoracic and Cardiovascular Surgery 2000 119, 1255-1261DOI: (10.1067/mtc.2000.105262) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Reflection coefficient (Sigma ) decreases with the initiation of CPB, indicating a modest increase in the microvascular permeability to protein. There is no statistically significant difference between groups. The Journal of Thoracic and Cardiovascular Surgery 2000 119, 1255-1261DOI: (10.1067/mtc.2000.105262) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Transvascular protein clearance increases with the initiation of CPB, indicating an increase in microvascular permeability to protein. Although transvascular protein clearance increases from wash down (P = .01, comparing wash down with 30-minute CPB), there is no statistical difference between groups. *Statistical significance within groups, comparing individual time points with wash down. The Journal of Thoracic and Cardiovascular Surgery 2000 119, 1255-1261DOI: (10.1067/mtc.2000.105262) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Tissue water (ileum) as measured by microgravimetrics. There is no statistically significant difference between groups. The Journal of Thoracic and Cardiovascular Surgery 2000 119, 1255-1261DOI: (10.1067/mtc.2000.105262) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions