Quantitative MRI of parallel changes of articular cartilage and underlying trabecular bone in degeneration E. Lammentausta, M.Sc., P. Kiviranta, B.M.,

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Presentation transcript:

Quantitative MRI of parallel changes of articular cartilage and underlying trabecular bone in degeneration E. Lammentausta, M.Sc., P. Kiviranta, B.M., J. Töyräs, Ph.D., M.M. Hyttinen, M.D., I. Kiviranta, M.D., Ph.D., M.T. Nieminen, Ph.D., J.S. Jurvelin, Ph.D. Osteoarthritis and Cartilage Volume 15, Issue 10, Pages 1149-1157 (October 2007) DOI: 10.1016/j.joca.2007.03.019 Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Test sites for articular cartilage and trabecular bone. SM=superomedial, SL=superolateral, CM=central medial, CL=central lateral, IM=inferomedial, and IL=inferolateral. Osteoarthritis and Cartilage 2007 15, 1149-1157DOI: (10.1016/j.joca.2007.03.019) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Localization of the sample sites for articular cartilage (black rectangles) and trabecular bone (white squares). Two locations were marked at each slice, one on medial and one on lateral facet. Capsules serving as localization markers and spin density reference were attached on a plastic film wrapped firmly around the patella. The ROI were chosen to be rectangular and approximately 10 pixels (3.125mm) wide for cartilage and 23 pixels (7.19mm) wide for bone. Osteoarthritis and Cartilage 2007 15, 1149-1157DOI: (10.1016/j.joca.2007.03.019) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Mean±SD values for cartilage variables divided into three groups according to the MS: group I (samples with no or minimal degeneration, the MS<4), group II (moderate degeneration, 4≤MS<8 and group III (advanced degeneration, MS≥8). The statistically significant differences (P<0.05) between groups are denoted with brackets. The number of samples in groups measured with different modalities is shown in Table I. Osteoarthritis and Cartilage 2007 15, 1149-1157DOI: (10.1016/j.joca.2007.03.019) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Mean±SD values for bone variables divided into three groups according to the MS: group I (samples with no or minimal degeneration, the MS<4), group II (moderate degeneration, 4≤MS<8 and group III (advanced degeneration, MS≥8). The statistically significant differences (P<0.05) between groups are denoted with brackets. The number of samples in groups measured with different modalities is shown in Table I. Osteoarthritis and Cartilage 2007 15, 1149-1157DOI: (10.1016/j.joca.2007.03.019) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Scatter plots of T2* relaxation time and BMD as a function of microscopically measured apparent bone volume fraction (BV/TVREF). In both cases the correlation coefficient is increased significantly when samples with MS<4 only are included. In subfigure (a) the correlation coefficient increases from 0.09 (not significant) to −0.86 (P<0.05). In subfigure (b) the coefficient changes from 0.58 (P<0.01) to 0.91 (P<0.01). In both cases the change of correlation coefficient is significant (P<0.05). The line is fitted to the sample group with MS<4. Osteoarthritis and Cartilage 2007 15, 1149-1157DOI: (10.1016/j.joca.2007.03.019) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions