New assessment of platelet deposition in small caliber vascular prostheses using technetium-99m apcitide scintigraphy in rabbit model Tomomi Hasegawa,

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Presentation transcript:

New assessment of platelet deposition in small caliber vascular prostheses using technetium-99m apcitide scintigraphy in rabbit model Tomomi Hasegawa, MD, PhD, Kenji Okada, MD, PhD, Yutaka Okita, MD, PhD Journal of Vascular Surgery Volume 44, Issue 4, Pages 840-845 (October 2006) DOI: 10.1016/j.jvs.2006.06.010 Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 1 Graft region of interest (ROI) in semi-quantitative analysis. By using the iSSPView image program, graft ROI (10 x 5 pixels) was traced on the scintigraphic image of vascular prosthesis and the platelet activity of the graft ROI was measured. Journal of Vascular Surgery 2006 44, 840-845DOI: (10.1016/j.jvs.2006.06.010) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 2 Radiolabeled platelet deposition of graft in quantitative analysis. Although there was no statistically significant difference in time-dependent changes of radiolabeled platelet deposition between both groups, the radiolabeled platelet deposition in Group I was significantly higher than that in Group II on each day after graft implantation. *P<0.001 vs. Group II. Journal of Vascular Surgery 2006 44, 840-845DOI: (10.1016/j.jvs.2006.06.010) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 3 Scintigraphic images of the grafts in visual analysis. Top, Group I (99mTc-apcitide scintigraphy): (A) POD 1, (B) POD 7, (C) POD10. Bottom, Group II (111In-platelet scintigraphy): (D) POD 1, (E) POD 7, (F) POD 10. Scintigraphic images in Group I were visualized earlier and more clearly than those in Group II. POD, postoperative day. Journal of Vascular Surgery 2006 44, 840-845DOI: (10.1016/j.jvs.2006.06.010) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 4 Platelet activity of graft ROI in semi-quantitative analysis. Although there was no statistically significant difference in time-dependent changes of platelet activity of graft ROI between both groups, the platelet activity in Group I was significantly higher than that in Group II on each day after graft implantation. *P<.01 vs. Group II. ROI, region of interest. Journal of Vascular Surgery 2006 44, 840-845DOI: (10.1016/j.jvs.2006.06.010) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 5 Correlation between platelet activity of graft ROI in semi-quantitative analysis and radiolabeled platelet deposition of graft in quantitative analysis. (A) Group I, (B) Group II. There was a significant correlation with high coefficient determination between the platelet activity and the radiolabeled platelet deposition in each group. ROI, region of interest. Journal of Vascular Surgery 2006 44, 840-845DOI: (10.1016/j.jvs.2006.06.010) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions