Does the degree of cyanosis affect myocardial adenosine triphosphate levels and function in children undergoing surgical procedures for congenital heart.

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Presentation transcript:

Does the degree of cyanosis affect myocardial adenosine triphosphate levels and function in children undergoing surgical procedures for congenital heart disease? Hani K. Najm, MD, MSca,c, W.Jack Wallen, MScd, Michael P. Belanger, AALASa,d, William G. Williams, MDa, John G. Coles, MDa,c, Glen S. Van Arsdell, MDa, Michael D. Black, MDa, Christine Boutin, MDb, Carin Wittnich, DVM,MSca,c,d The Journal of Thoracic and Cardiovascular Surgery Volume 119, Issue 3, Pages 515-524 (March 2000) DOI: 10.1016/S0022-5223(00)70131-0 Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 1 Myocardial biopsy protocol. Biopsy (1) , baseline or control; Biopsy (2) , 15 minutes of ischemia; Biopsy (3) , end-ischemia; and Biopsy (4) , 15 minutes of reperfusion. The Journal of Thoracic and Cardiovascular Surgery 2000 119, 515-524DOI: (10.1016/S0022-5223(00)70131-0) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 2 Myocardial ATP levels at different time intervals. (A ) Baseline, (B ) 15 minutes of ischemia, (C ) end-ischemia, and (D ) 15 minutes of reperfusion in groups I, II, and III. *Significance versus group I. †Significance versus group II. The Journal of Thoracic and Cardiovascular Surgery 2000 119, 515-524DOI: (10.1016/S0022-5223(00)70131-0) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 3 Percent recovery of ATP from end-ischemia to 15 minutes of reperfusion. *Significance versus group I. The Journal of Thoracic and Cardiovascular Surgery 2000 119, 515-524DOI: (10.1016/S0022-5223(00)70131-0) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 4 Ventricular EF in (A ) preoperative, (B ) intraoperative, and (C ) postoperative assessment in groups I, II, and III. *Significance versus group I. †Significance versus group II. The Journal of Thoracic and Cardiovascular Surgery 2000 119, 515-524DOI: (10.1016/S0022-5223(00)70131-0) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 5 Clinical outcome. (A ) Duration of inotropic support, (B ) duration of ventilatory support, (C ) duration of ICU stay, and (D ) duration of hospital stay in groups I, II, and III. *Significance versus group I. †Significance versus group II. The Journal of Thoracic and Cardiovascular Surgery 2000 119, 515-524DOI: (10.1016/S0022-5223(00)70131-0) Copyright © 2000 Mosby, Inc. Terms and Conditions