Diversity of methods utilized to model neurological diseases using patient‐derived iPSCs Diversity of methods utilized to model neurological diseases using.

Slides:



Advertisements
Similar presentations
47-year-old with progressive upper limb weakness Teaching NeuroImages Neurology Resident and Fellow Section © 2014 American Academy of Neurology.
Advertisements

Noninvasive Examination of Amyotrophic Lateral Sclerosis Using Surface Electromyography Ping Zhou, PhD.
H. influenzae genes differentially regulated during growth in complex media and during lung infection in the presence of corticosteroids AVenn diagram.
Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared.
by Edward J. Goetzl, Adam Boxer, Janice B. Schwartz, Erin L
Expression analyses of KLK7 mRNA in the brains of AD patients
The HDAC3 inhibitor suppresses SPOP‐mutated prostate cancer cell growth The HDAC3 inhibitor suppresses SPOP‐mutated prostate cancer cell growth A22Rv1.
Spatial and temporal expression patterning of dysregulated genes from neurons in vivo Spatial and temporal expression patterning of dysregulated genes.
PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection Proportion.
Chia-Wei Lin, MS, Stephanie J. Kalb, PhD, Wei-Shi Yeh, PhD 
Figure 2 Flow chart of patients who met the inclusion/exclusion criteria for the study Flow chart of patients who met the inclusion/exclusion criteria.
AAV8‐hAAT‐FGF21 treatment improves liver fibrosis
CAR T cell dose and percentages of CAR‐positive cells within CAR T cell products CAR T cell dose and percentages of CAR‐positive cells within CAR T cell.
TR suppresses the assembly of NLRP3 inflammasome
Preceding knockdown of FoxO3 reduces inhibitory effect of UCN‐01 on human lung fibroblast proliferation and myofibroblast transdifferentiation in response.
Phenogenetic networks of genes linked to Alzheimer's and Parkinson's disease reveal concordant phenotypes Phenogenetic networks of genes linked to Alzheimer's.
Figure 3 Genetic pleiotropy in ALS
Clinical testing of calcineurin inhibitors cyclosporine A and tacrolimus in autoimmune disorders Clinical testing of calcineurin inhibitors cyclosporine.
Increased IFNγ producing CD4+ T cells in the spleen drives the enhanced splenic IFNγ on 6 dpi during concurrent co‐infection Increased IFNγ producing CD4+
No neurodegenerative phenotype observed in single Aph1a and Aph1bc cKO Cre+ mice No neurodegenerative phenotype observed in single Aph1a and Aph1bc cKO.
Negligible T22‐GFP‐H6‐FdU biodistribution or toxicity on non‐tumor tissues Negligible T22‐GFP‐H6‐FdU biodistribution or toxicity on non‐tumor tissues AUndetectable.
Correlation between Aβ deposition in the brain (PET) and the Aβ secondary structure distribution in plasma Correlation between Aβ deposition in the brain.
[68Ga]Pentixafor PET/CT and [18F]FDG PET/CT A–DMaximum intensity projections (MIP) of [68Ga]Pentixafor (A) and [18F]FDG PET/CT (B) of a 68‐year‐old male.
Modules with causal links to ALS are associated with inflammation and enriched with TDP‐43 protein–protein interactions (PPIs)‏ Modules with causal links.
Distribution of psychrophile genomes and metagenomes in different cold ecosystems(A) Pie chart of the relative proportions of sequenced psychrophile genomes.
Inhibition of JNK signaling in breast cancer cells and lung colonization in a xenograft mouse model Inhibition of JNK signaling in breast cancer cells.
Figure 3 Transcripts of the splicing mutation (c
Expression of PD‐1 on PBMC and malignant exudate T cells
Expression and occupancy of a set of transcription factors corresponding to the identified motifs at FAIRE peaks Expression and occupancy of a set of transcription.
Integrated protein co‐expression and differential expression across the ALS‐FTD disease continuum Integrated protein co‐expression and differential expression.
Validation of astrocyte and microglial proteomic markers that increase across the ALS‐FTD spectrum Validation of astrocyte and microglial proteomic markers.
PERK activator treatment protects neurite network
Astrocyte and microglial markers associated with neuroinflammation are increased across the ALS‐FTD spectrum Astrocyte and microglial markers associated.
Figure 3 Temporal trends in FALS incidence
Feature‐based COG enrichment analysis
Characterization of super‐enhancers in WT and KO macrophages
Schematic diagram of the proposed model depicting the functional relationship between EGFR and FASN in TKI resistance within EGFR mutant NSCLC cells Schematic.
TGF‐β1 treatment induces the chromatin binding of Smad2/3/4 in 4T1 cells TGF‐β1 treatment induces the chromatin binding of Smad2/3/4 in 4T1 cells A, BWestern.
IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice ARepresentative.
Assessment of intracerebral micro‐hemorrhages in APP23‐transgenic mice, dosed orally with CNP520 at 30 mg/kg for 3 months Assessment of intracerebral micro‐hemorrhages.
Association of total disease burden and disease progression with age‐adjusted blood heteroplasmy Association of total disease burden and disease progression.
Association of total disease burden with age, m
Comparison of proteomics and RNA‐Seq data.
Surface biotinylation and fate of TREM2
GPR120 deficiency alters the expression of genes involved in glucose and lipid metabolism in BAT GPR120 deficiency alters the expression of genes involved.
Classification of the 1458 identified proteins into molecular functions. Classification of the 1458 identified proteins into molecular functions. The pie.
Reproducibility of DeathPro drug screens
WES identification of heterozygous compound mutations in ALPI
Scheme of FGF‐dependent regulation of TGFβ signaling in smooth muscle cells and endothelial cells Scheme of FGF‐dependent regulation of TGFβ signaling.
Quantification of phenotypes by genes and developmental stage
Melting behavior of protein complexes
Schematic overview of the immuno‐infrared‐sensor, the assay read‐out, and BioFINDER and ESTHER study design Schematic overview of the immuno‐infrared‐sensor,
MiR‐34a‐5p functionally contributes to arrested lung alveolarization in response to hyperoxia miR‐34a‐5p functionally contributes to arrested lung alveolarization.
Therapeutic role of TR in HFD‐established diabetic mice
In vitro kinetics and binding studies of inhibitory compounds (PRK and SRB) MtArgJ In vitro kinetics and binding studies of inhibitory compounds (PRK and.
Re‐expression of the AXIN1 coding sequence re‐sensitizes VACO6R cells to PORCN inhibition Re‐expression of the AXIN1 coding sequence re‐sensitizes VACO6R.
Target disease and target populations for 21st century vaccine developmentIncluded in the list are the agents of infectious diseases for which vaccines.
Etifoxine modulation of T‐cell activity during EAE
Dual‐recombinase fluorescence lineage tracing of EMT in KPF (FSF‐KrasG12D/+;Trp53frt/+;Pdx1‐Flp);αSMA‐Cre;R26Dual mice Dual‐recombinase fluorescence lineage.
Tissue‐specific differences in the levels of CoQ9, CoQ10, and DMQ9, and in the DMQ9/CoQ9 ratio after β‐RA treatment in Coq9R239X mice Tissue‐specific differences.
Genomewide profiling of chromatin accessibility in prostate cancer specimens Genomewide profiling of chromatin accessibility in prostate cancer specimens.
POLG defects cause degeneration of enhancer‐active regions of CNS
P2X4R blockade increases pro‐inflammatory gene expression after EAE
GDF11 induces myotube atrophy in vitro
Supraphysiological levels of GDF11 cause atrophy of striated muscle in vivo Supraphysiological levels of GDF11 cause atrophy of striated muscle in vivo.
Figure 1 Percentage distribution according to severity of baseline behavioral changes in behavioral variant frontotemporal dementia (bvFTD) and semantic.
Figure 4. The N:M ratio is significantly increased in patients with ALS and correlates with disease progression The N:M ratio is significantly increased.
Indications for ventilation in adults
Figure 2. Percentage of CD16− monocytes in the blood is reduced during disease progression Percentage of CD16− monocytes in the blood is reduced during.
Pie chart showing percentages of various diseases diagnosed in 2014–2015 among children during childhood screening for blindness. Pie chart showing percentages.
Presentation transcript:

Diversity of methods utilized to model neurological diseases using patient‐derived iPSCs Diversity of methods utilized to model neurological diseases using patient‐derived iPSCs Pie charts illustrating the percentage distribution of disease groups and specific diseases.Venn diagram showing unique and shared experimental techniques among the examined articles.Minimal information about iPSC experiments (MiPSCE). Percentage of studies with or without the information for each category is depicted by color. Complete descriptions of the categories can be found in Materials and Methods. SMA, spinal muscular atrophy; ALS, amyotrophic lateral sclerosis; FTD, frontotemporal dementia. Ethan W Hollingsworth et al. EMBO Mol Med. 2017;emmm.201708191 © as stated in the article, figure or figure legend