C. Hällsjö Sander, M. Hallbäck, M. Wallin, P. Emtell, A. Oldner, H

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Presentation transcript:

Novel continuous capnodynamic method for cardiac output assessment during mechanical ventilation C. Hällsjö Sander, M. Hallbäck, M. Wallin, P. Emtell, A. Oldner, H. Björne British Journal of Anaesthesia Volume 112, Issue 5, Pages 824-831 (May 2014) DOI: 10.1093/bja/aet486 Copyright © 2014 The Author(s) Terms and Conditions

Fig 1 Haemodynamic data for all protocolled interventions. Left y-axis represents cardiac output (litre min−1, as measured by the ultrasonic reference method, COTS). Right y-axis represents MAP (mm Hg), HR (beats min−1), and SVR (mm Hg litre min−1). Each haemodynamic challenge was followed by a baseline stabilization period. Data are presented as mean (sem), n=6–10. British Journal of Anaesthesia 2014 112, 824-831DOI: (10.1093/bja/aet486) Copyright © 2014 The Author(s) Terms and Conditions

Fig 2 CO data (litre min−1) obtained by the ultrasonic reference method (COTS), the capnodynamic method (COEPBF), and pulmonary artery catheter thermodilution (COPAC) at baseline and during haemodynamic interventions. Each haemodynamic challenge was followed by a baseline stabilization period. Data are presented as mean (sem), n=6–10. British Journal of Anaesthesia 2014 112, 824-831DOI: (10.1093/bja/aet486) Copyright © 2014 The Author(s) Terms and Conditions

Fig 3 Bland–Altman plot for 112 paired CO values obtained using the new capnodynamic method (COEPBF) and the ultrasonic flow probe (COTS) as the reference method during haemodynamic interventions in a porcine model (n=6–10). Black dotted lines represent mean difference (bias) and limits of agreement [bias (1.96) sd]. British Journal of Anaesthesia 2014 112, 824-831DOI: (10.1093/bja/aet486) Copyright © 2014 The Author(s) Terms and Conditions

Fig 4 Four-quadrant plot showing the trending abilities for the capnodynamic method (COEPBF) and thermodilution (COPAC), using the ultrasonic flow probe (COTS) as reference method. Fifty-six paired delta CO values (litre min−1) were generated from measurements before and during each haemodynamic intervention. The correlation coefficients for both test methods are shown in the figure. Data points plotted in one of the two quadrants of agreement were considered concordant. A 15% (0.4 litre min−1) exclusion zone of central data is displayed. British Journal of Anaesthesia 2014 112, 824-831DOI: (10.1093/bja/aet486) Copyright © 2014 The Author(s) Terms and Conditions

Fig 5 Polar plot for the capnodynamic method COEPBF using the ultrasonic flow probe COTS as reference method. The radial length is the mean of the pairwise delta values of the reference method and the test method (litre min−1). Data spread closely to the polar axis indicates good trending. Lines indicate ±30° concordance limits. British Journal of Anaesthesia 2014 112, 824-831DOI: (10.1093/bja/aet486) Copyright © 2014 The Author(s) Terms and Conditions

Fig 6 Polar plot for PAC thermodilution (COPAC) with the ultrasonic flow probe (COTS) as reference method. The radial length is the mean of the pairwise delta values of the reference method and the test method (litre min−1). Data spread closely to the polar axis indicate good trending. Lines indicate ±30° concordance limits. British Journal of Anaesthesia 2014 112, 824-831DOI: (10.1093/bja/aet486) Copyright © 2014 The Author(s) Terms and Conditions