Volume 66, Issue 6, Pages (December 2004)

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Volume 66, Issue 6, Pages 2422-2428 (December 2004) Creatine supplementation does not decrease total plasma homocysteine in chronic hemodialysis patients Youri E.C. Taes, Joris R. Delanghe, Dirk De Bacquer, Michel Langlois, Lut Stevens, Inge Geerolf, Norbert H. Lameire, An S. De Vriese Kidney International Volume 66, Issue 6, Pages 2422-2428 (December 2004) DOI: 10.1111/j.1523-1755.2004.66019.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Overview of homocysteine and creatine metabolism. THF: tetrahydrofolate; 5CH3-THF: 5-methyltetrahydrofolate; 5,10-CH2-THF: 5,10 methylene tetrahydrofolate; Ser: serine; Gly: glycine; SAM: S-adenosyl methionine; SAH: S-adenosyl homocysteine; Hcy: homocysteine; Met: methionine. Enzymes are (1) arginine:glycine amidinotransferase (AGAT); (2) methionine adenosyltransferase; (3) guanidinoacetate methyltransferase (GAMT); (4) S-adenosyl homocysteine hydrolase; (5) methionine synthase; (6) 5,10-CH2-THF reductase; (7) serine-hydroxy methyltransferase; (8) cystathionine-β–synthase. Kidney International 2004 66, 2422-2428DOI: (10.1111/j.1523-1755.2004.66019.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 Treatment schedule. Kidney International 2004 66, 2422-2428DOI: (10.1111/j.1523-1755.2004.66019.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 3 Plasma homocysteine (tHcy) and creatine concentrations in both treatment periods. Black bars represent concentrations before treatment, whereas gray bars represent concentrations after treatment. Creatine concentrations were significantly higher in the creatine groups compared to the placebo groups (*P < 0.0001). No difference in tHcy concentrations was observed. Kidney International 2004 66, 2422-2428DOI: (10.1111/j.1523-1755.2004.66019.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 4 Relationship between plasma homocysteine (tHcy) and plasma creatine (A), plasma folate (B), Kt/Vurea (C), and plasma creatinine concentrations (D). (A) and (B) represent values (homocysteine, creatine, folate) after treatment; (C) and (D) represent baseline values (homocysteine, creatinine, Kt/Vurea). Kidney International 2004 66, 2422-2428DOI: (10.1111/j.1523-1755.2004.66019.x) Copyright © 2004 International Society of Nephrology Terms and Conditions