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Volume 3, Issue 6, Pages 515-525 (June 2016) Effectiveness of an integrated telehealth service for patients with depression: a pragmatic randomised controlled trial of a complex intervention Prof Chris Salisbury, MD, Prof Alicia O'Cathain, PhD, Louisa Edwards, PhD, Clare Thomas, PhD, Daisy Gaunt, MSc, Sandra Hollinghurst, PhD, Prof Jon Nicholl, DSc, Shirley Large, PhD, Prof Lucy Yardley, PhD, Prof Glyn Lewis, PhD, Alexis Foster, MPH, Katy Garner, PhD, Kimberley Horspool, MSc, Mei-See Man, PhD, Anne Rogers, PhD, Catherine Pope, PhD, Padraig Dixon, PhD, Alan A Montgomery, PhD The Lancet Psychiatry Volume 3, Issue 6, Pages 515-525 (June 2016) DOI: 10.1016/S2215-0366(16)00083-3 Copyright © 2016 Salisbury et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Trial profile Primary outcome incomplete indicates patients who did not answer enough questions in their Patient Health Questionnaire-9 to allow calculation of a valid score. The Lancet Psychiatry 2016 3, 515-525DOI: (10.1016/S2215-0366(16)00083-3) Copyright © 2016 Salisbury et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Distribution of Healthlines telephone encounters from 295 patients Data about use of the intervention were missing for 12 participants who received the intervention. The Lancet Psychiatry 2016 3, 515-525DOI: (10.1016/S2215-0366(16)00083-3) Copyright © 2016 Salisbury et al. Open Access article distributed under the terms of CC BY Terms and Conditions