Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis J.M. Hoch,

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Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis J.M. Hoch, C.G. Mattacola, J.M. Medina McKeon, J.S. Howard, C. Lattermann Osteoarthritis and Cartilage Volume 19, Issue 12, Pages 1396-1404 (December 2011) DOI: 10.1016/j.joca.2011.09.005 Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Summary of search history and included studies. Osteoarthritis and Cartilage 2011 19, 1396-1404DOI: (10.1016/j.joca.2011.09.005) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 A Forest plot depicting the calculated ESs of sCOMP in patients with radiographically diagnosed knee OA when compared to controls. The diamond at the bottom of the plot represents the overall ES. Osteoarthritis and Cartilage 2011 19, 1396-1404DOI: (10.1016/j.joca.2011.09.005) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 A funnel plot of standard error by Hedges’s g using Duval and Tweedie’s Trim and Fill method to assess publication bias of the studies used to determine if sCOMP is elevated in patients with radiographically diagnosed knee OA when compared to controls. Osteoarthritis and Cartilage 2011 19, 1396-1404DOI: (10.1016/j.joca.2011.09.005) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 A Forest plot depicting the calculated ESs of sCOMP exist when comparing patients with differing radiographic knee OA severities compared to controls. Each of the diamonds represents the overall ES for each of the comparisons made for each (K/L) classification. Osteoarthritis and Cartilage 2011 19, 1396-1404DOI: (10.1016/j.joca.2011.09.005) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 A funnel plot of standard error by Hedges’s g using Duval and Tweedie’s Trim and Fill method to assess publication bias of the comparisons used to determine if differences in sCOMP levels exist when comparing differing knee OA severities when compared to healthy controls. Osteoarthritis and Cartilage 2011 19, 1396-1404DOI: (10.1016/j.joca.2011.09.005) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 A Forest plot depicting the calculated ESs for large groups (n > 10) and small groups (n < 10) used to answer the second question. Osteoarthritis and Cartilage 2011 19, 1396-1404DOI: (10.1016/j.joca.2011.09.005) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions