Correlating in vivo anaesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isoflurane †‡

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Correlating in vivo anaesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isoflurane †‡ M.T. Alkire, R.J. Haier British Journal of Anaesthesia Volume 86, Issue 5, Pages 618-626 (May 2001) DOI: 10.1093/bja/86.5.618 Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 1 Brain regions where relative glucose metabolic rate values differ significantly between the i.v. anaesthetic agent propofol (n=8), a presumed GABA agonist (white bars) and the inhalation anaesthetic agent isoflurane (n=5; dark bars). Data are mean (sd). *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001. British Journal of Anaesthesia 2001 86, 618-626DOI: (10.1093/bja/86.5.618) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 2 Regression plot showing a significant linear relationship between the regional metabolic reductions occurring during propofol anaesthesia in humans and the known regional benzodiazepine ([3H]diazepam) receptor densities. The figure shows that brain metabolism during propofol anaesthesia decreases more in those brain regions that have more benzodiazepine receptors. The line through the data is the regression line. British Journal of Anaesthesia 2001 86, 618-626DOI: (10.1093/bja/86.5.618) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 3 Regression plot showing an apparent lack of a significant relationship between the regional metabolic reductions occurring during isoflurane anaesthesia in humans and the known regional benzodiazepine ([3H]diazepam) receptor densities. These data do not directly support a GABAA complex mediated mechanism for the production of the anaesthetic state associated with isoflurane. British Journal of Anaesthesia 2001 86, 618-626DOI: (10.1093/bja/86.5.618) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 4 Regression plot showing a significant relationship between the regional metabolic reductions occurring during isoflurane anaesthesia in humans and the known regional muscarinic acetylcholine ([3H]quinuclidinyl benzilate) receptor densities. British Journal of Anaesthesia 2001 86, 618-626DOI: (10.1093/bja/86.5.618) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 5 Regression plot showing a significant negative relationship between the regional metabolic reductions occurring during propofol anaesthesia and the known regional opiate ([3H]naloxone) receptor densities. British Journal of Anaesthesia 2001 86, 618-626DOI: (10.1093/bja/86.5.618) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 6 Regression plot showing a positive trend exists between the regional metabolic reductions occurring during isoflurane anaesthesia and the known regional opiate ([3H]naloxone) receptor densities. Note that the direction of the correlation is opposite of that shown for propofol in Figure 5. British Journal of Anaesthesia 2001 86, 618-626DOI: (10.1093/bja/86.5.618) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions