L. -C. Chu, M. -L. Tsaur, C. -S. Lin, Y. -C. Hung, T. -Y. Wang, C. -C

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Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats L.-C. Chu, M.-L. Tsaur, C.-S. Lin, Y.-C. Hung, T.-Y. Wang, C.-C. Chen, J.-K. Cheng British Journal of Anaesthesia Volume 106, Issue 5, Pages 699-705 (May 2011) DOI: 10.1093/bja/aer063 Copyright © 2011 The Author(s) Terms and Conditions

Fig 1 Effect of continuous intrathecal infusion of gabapentin on L5/6 spinal nerve ligation-induced mechanical allodynia, measured as paw withdrawal threshold to von Frey filament stimulus. Bar above the x-axis represents intrathecal infusion with saline (1 µl h−1) or gabapentin (20 μg h−1) for 7 days. Data are presented as median and IQR. *P<0.05 vs the sham/saline group; +P<0.05 vs the ligation/saline group (Mann–Whitney test, n=8). British Journal of Anaesthesia 2011 106, 699-705DOI: (10.1093/bja/aer063) Copyright © 2011 The Author(s) Terms and Conditions

Fig 2 Effect of continuous intrathecal infusion of gabapentin on L5/6 spinal nerve ligation-induced thermal hyperalgesia measured as paw withdrawal latency to radiant heat stimulus. Bar above the x-axis represents intrathecal infusion with saline (1 µl h−1) or gabapentin (20 µg h−1) for 7 days. Data are presented as the median and IQR. *P<0.05 vs the sham/saline group; +P<0.05 vs the ligation/saline group (Mann–Whitney test, n=8). British Journal of Anaesthesia 2011 106, 699-705DOI: (10.1093/bja/aer063) Copyright © 2011 The Author(s) Terms and Conditions

Fig 3 Effects of intrathecal gabapentin infusion on motor co-ordination, measured as time spent on accelerating rota-rod (a) and body weight changes (b). Bar above the x-axis represents intrathecal treatment with saline or gabapentin. Data are presented as median and IQR. *P<0.05 vs the saline group (Mann–Whitney test, n=6). British Journal of Anaesthesia 2011 106, 699-705DOI: (10.1093/bja/aer063) Copyright © 2011 The Author(s) Terms and Conditions

Fig 4 Representative photomicrograph showing haematoxylin and eosin staining of lumbar spinal cord sections from sham-operated (a and b) and nerve-ligated (c) rats after receiving intrathecal infusion of normal saline 1 µl h−1 (a) or gabapentin 40 µg h−1 (b and c) for 7 days. All rats were scored at zero (n=6). 1–9, Higher magnification images of dorsal, medial, and ventral insets in a–c, respectively. Scale bar: 500 µm (a–c), 50 µm (1–9). British Journal of Anaesthesia 2011 106, 699-705DOI: (10.1093/bja/aer063) Copyright © 2011 The Author(s) Terms and Conditions

Fig 5 Representative photomicrograph showing toluidine blue staining of the cauda equina fascicle sections from sham-operated (a and b) and nerve-ligated (c) rats after receiving intrathecal infusion of saline 1 µl h−1 (a) or gabapentin 40 µg h−1 (b and c) for 7 days. (a1–c1) Higher magnification images of the insets in (a–c), respectively. Injury scores of the three groups were not significantly different (n=6). Scale bar: 20 µm. British Journal of Anaesthesia 2011 106, 699-705DOI: (10.1093/bja/aer063) Copyright © 2011 The Author(s) Terms and Conditions