New Insights into Genome Structure: Genes of a Feather Stick Together

Slides:

Advertisements

Similar presentations

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.

Advertisements

The Genetic Makeup of the Drosophila piRNA Pathway Dominik Handler, Katharina Meixner, Manfred Pizka, Kathrin Lauss, Christopher Schmied, Franz Sebastian.

Profiling by Image Registration Reveals Common Origin of Annelid Mushroom Bodies and Vertebrate Pallium Raju Tomer, Alexandru S. Denes, Kristin Tessmar-Raible,

HnRNP L and HnRNP A1 Induce Extended U1 snRNA Interactions with an Exon to Repress Spliceosome Assembly Ni-Ting Chiou, Ganesh Shankarling, Kristen W. Lynch.

Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

An Ancient Mechanism for Splicing Control: U11 snRNP as an Activator of Alternative Splicing Jens Verbeeren, Elina H. Niemelä, Janne J. Turunen, Cindy.

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Cost of Unneeded Proteins in E. coli Is Reduced after Several Generations in Exponential Growth Irit Shachrai, Alon Zaslaver, Uri Alon, Erez Dekel Molecular.

Distinct Properties of Cell-Type-Specific and Shared Transcription Factor Binding Sites Jason Gertz, Daniel Savic, Katherine E. Varley, E. Christopher.

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres Emilio Cusanelli, Carmina Angelica.

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial- Mesenchymal Transition Min-Zu Wu, Ya-Ping Tsai, Muh-Hwa Yang, Chi-Hung Huang,

The BCL-2 Family Reunion Jerry E. Chipuk, Tudor Moldoveanu, Fabien Llambi, Melissa J. Parsons, Douglas R. Green Molecular Cell Volume 37, Issue 3, Pages.

The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel

Genome Organization: Cohesin on the Move

Volume 58, Issue 5, Pages (June 2015)

Can We Just Say: Transcription Second?

Central Dogma Goes Digital

Sonja Schmid, Thorsten Hugel Molecular Cell

A Flick of the Tail Keeps the Circadian Clock in Line

Inter-chromosomal Contact Properties in Live-Cell Imaging and in Hi-C

Unweaving the Autism Spectrum

Stopping the Clock with MYC

Structural Insights into Riboswitch Control of the Biosynthesis of Queuosine, a Modified Nucleotide Found in the Anticodon of tRNA Mijeong Kang, Robert.

Wt1 Flip-Flops Chromatin in a CTCF Domain

Adding Specificity to Artificial Transcription Activators

Pioneering a Global Cure for Chronic Hepatitis C Virus Infection

Methed-Up FOXOs Can't In-Akt-ivate

Volume 58, Issue 2, Pages (April 2015)

A CTCF Code for 3D Genome Architecture

Skill Development in Graduate Education

Wenlian Qiao, Peter W. Zandstra Cell Stem Cell

More Division of Labor at the Eukaryotic Replication Fork

How To Choose a Good Scientific Problem

A New Link in the Chain from Amino Acids to mTORC1 Activation

A CRISPR Connection between Chromatin Topology and Genetic Disorders

Putting Two Heads Together to Build a Better Brain

Chromatin Meets Its Organizers

Karin Johanna Ferrari, Elisa Lavarone, Diego Pasini Molecular Cell

lncRNA Structure: Message to the Heart

William G. Kaelin, Peter J. Ratcliffe Molecular Cell

Eukaryotic Transcription Activation: Right on Target

The Birth of the 3D Genome during Early Embryonic Development

Stephen P. Muench, Martin van der Laan Molecular Cell

The Hierarchy of the 3D Genome

MicroRNAs and Viral Infection

A Finer Print Than TADs: PRC1-Mediated Domains

Nuclear PI5P, Uhrf1, and the Road Not Taken

Breaching the Boundaries that Safeguard against Repression

Watching the Fly Brain Learn

Structural Insights into Riboswitch Control of the Biosynthesis of Queuosine, a Modified Nucleotide Found in the Anticodon of tRNA Mijeong Kang, Robert.

Transferring Death: A Role for tRNA in Apoptosis Regulation

Genome Organization: Cohesin on the Move

For HIV, It's Never Too Late to Grow Up

Identification of PARP-Specific ADP-Ribosylation Targets Reveals a Regulatory Function for ADP-Ribosylation in Transcription Elongation Mario Leutert,

Silencing the Transcriptome's Dark Matter: Mechanisms for Suppressing Translation of Intergenic Transcripts Kellie S. Bickel, David R. Morris Molecular.

Denes Hnisz, Daniel S. Day, Richard A. Young Cell

Switches, Switches, Every Where, In Any Drop We Drink

Volume 22, Issue 4, Pages (April 2018)

How To Choose a Good Scientific Problem

Volume 61, Issue 2, Pages (January 2016)

Volume 58, Issue 2, Pages (April 2015)

The 3D Genome in Transcriptional Regulation and Pluripotency

Chaos Controlled: Discovery of a Powerful Amyloid Inhibitor

A New Cohesive Team to Mediate DNA Looping

Volume 25, Issue 2, Pages (January 2007)

Many Roads Lead to the Lipid Droplet

Gene Regulation in the Postgenomic Era: Technology Takes the Wheel

Molecular Chaperones in Cellular Protein Folding: The Birth of a Field

Presentation transcript:

New Insights into Genome Structure: Genes of a Feather Stick Together Denes Hnisz, Richard A. Young Molecular Cell Volume 67, Issue 5, Pages 730-731 (September 2017) DOI: 10.1016/j.molcel.2017.08.023 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Mechanisms Structuring the Genome (A) Topologically Associating Domains (TADs). (B) Top: high-resolution Hi-C in Rowley et al. (2017) reveals small compartmental domains at the boundaries of some TADs in Drosophila. Bottom: molecular underpinnings of TAD boundaries: cohesin associated CTCF-CTCF loops, and gene-gene interactions. (C) Model of genome structuring through phase separation of transcriptional activators and repressors. Molecular Cell 2017 67, 730-731DOI: (10.1016/j.molcel.2017.08.023) Copyright © 2017 Elsevier Inc. Terms and Conditions