Figure 1 Cancer stem cell plasticity and stem cell homeostasis in the gut Figure 1 | Cancer stem cell plasticity and stem cell homeostasis in the gut.

Slides:

Advertisements

Similar presentations

Figure 4 PET imaging in experimental pancreatic cancer

Advertisements

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Nick Barker, Hans Clevers Gastroenterology

Figure 4 The gut microbiota directly influences T-cell differentiation

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

promotes the oncogenic activity of CagA

Figure 3 Neutrophils in liver inflammation

Figure 5 Dendritic cells in liver inflammation

Figure 1 Contribution of the gut microbiota

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 6 Injection of mesenchymal stem cells in perianal fistulas

Figure 1 Patients cured of HCV infection

Figure 1 Gut microorganisms at the intersection of several diseases

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 7 Clinical options for HCC therapy

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 1 Towards precision PRRT for neuroendocrine tumours

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 2 Effect of PPIs on gastric physiology

Figure 6 Combination therapy for HCC

Figure 2 Modelling the effect of HCV treatment on reinfection in people who inject drugs Figure 2 | Modelling the effect of HCV treatment on reinfection.

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 4 Oncogenic KRAS and inflammation

Figure 2 Switching of biologic agents and biosimilars

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 1 An overview of the TIMER microbiota–host

Figure 3 Example wireless motility recording

Nat. Rev. Urol. doi: /nrurol

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 1 Exosomes with siRNAs targeting

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

to the liver and promote patient-derived xenograft tumour growth

Figure 7 Example colonic high-resolution manometry

Figure 1 Pseudorelaxation as a consequence of

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

different types of liver cells

Figure 2 13C-octanoic acid gastric emptying breath test

Figure 1 Median coverage and distribution by

Figure 3 Serotonin influences many peripheral tissues

in the UK (1961–2012), France (1961–2014) and Italy (1961–2010)

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 5 Representative barium defecography images

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 1 Brain–gut axis Brain–gut axis. Schematic of the brain–gut axis, including inputs from the gut microbiota, the ENS, the immune system and the external.

Figure 7 T cells in liver inflammation

Figure 3 Examples of gene expression heterogeneity

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 6 Assessment of colonic transit time with radiopaque markers

Figure 2 New therapeutic approaches in IBD with their specific targets

Figure 5 Systems biological model of IBS

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 1 New therapeutic approaches in IBD therapy based on blockade of T-cell homing and retention Figure 1 | New therapeutic approaches in IBD therapy.

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Nat. Rev. Clin. Oncol. doi: /nrclinonc

Figure 2 Lifelong influences on the gut microbiome from

Nick Barker, Alexander van Oudenaarden, Hans Clevers Cell Stem Cell

Volume 28, Issue 6, Pages (December 2015)

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 8 Assessment of colonic tone using a barostat device

Figure 1 The spread of colorectal cancer metastases

Presentation transcript:

Figure 1 Cancer stem cell plasticity and stem cell homeostasis in the gut Figure 1 | Cancer stem cell plasticity and stem cell homeostasis in the gut. The panel on the left illustrates the influence of the microenvironment on colorectal cancer stem cell (CSC) plasticity and tumour survival. The upper right panel highlights the importance of R-spondin 3 (RSPO3) production by myofibroblasts for gastric stem cell activity. Elevated RSPO3 expression in response to Helicobacter pylori infection increases stem cell activity to combat the infection. The lower right panel shows Paneth cells supplying lactate for neighbouring stem cell metabolism in the intestinal crypt, and the cooperative effects of WNT–frizzled (WNT–FZD) and leucine-rich repeat-containing G-protein coupled receptor 5–RSPO (LGR5–RSPO) signalling on intestinal stem cell function. Barker, N. (2018) Digesting recent stem cell advances in the gut Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2017.176