Identification of Desmogleins as Disease Targets

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Presentation transcript:

Identification of Desmogleins as Disease Targets Cory L. Simpson, Kathleen J. Green Journal of Investigative Dermatology Volume 127, Pages E15-E16 (January 2007) DOI: 10.1038/sj.skinbio.6250004 Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Desmogleins are targeted in epidermal blistering diseases. Dsg1 is expressed most highly in the superficial epidermis, whereas Dsg3 is more restricted to the lower layers. (Left) In pemphigus vulgaris (PV), autoantibodies (PV-IgG) bind Dsg3 and result in splitting near the basal layer of the epidermis. (Right) Binding of Dsg1 by PF-IgG in pemphigus foliaceus (PF) or cleavage by ETA in staphylococcal scalded skin syndrome (SSSS) leads to superficial acantholysis. Journal of Investigative Dermatology 2007 127, E15-E16DOI: (10.1038/sj.skinbio.6250004) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions